Diabetes potentiates acetylcholine-induced relaxation in rabbit renal arteries
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Diabetes potentiates acetylcholine-induced relaxation in rabbit renal arteries

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Diabetes potentiates acetylcholine-induced relaxation in rabbit renal arteries

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dc.contributor.author Alabadí Ferrer, José Antonio
dc.contributor.author Miranda Alonso, Francisco Javier
dc.contributor.author Lloréns, Silvia
dc.contributor.author Ruiz de Apodaca, Rosa F.
dc.contributor.author Centeno Guil, José M.
dc.contributor.author Alborch Domínguez, Enrique
dc.date.accessioned 2013-12-09T14:07:15Z
dc.date.available 2013-12-09T14:07:15Z
dc.date.issued 2001
dc.identifier.uri http://hdl.handle.net/10550/32084
dc.description.abstract The response of rabbit renal arteries to acetylcholine and its endothelial modulation in diabetes were investigated. Acetylcholine induced concentration-related endothelium-dependent relaxation of renal arteries that was significantly more potent in diabetic rabbits than in control rabbits. Pretreatment with NG-nitro-L-arginine L-NOArg., indomethacin, or L-NOArg plus indomethacin induced partial inhibition of acetylcholine-induced relaxation. Inhibition induced by L-NOArg plus indomethacin was significantly higher in arteries from diabetic rabbits than in arteries from control rabbits. In renal arteries depolarised with KCl 30 mM and incubated with L-NOArg plus indomethacin, acetylcholine-induced relaxation was almost abolished in both groups of rabbits and this response was not different from that obtained in arteries without endothelium. Sodium nitroprusside induced concentration-dependent relaxation of renal arteries from control and diabetic rabbits without significant differences between the two groups of animals. These results suggest that diabetes potentiates the acetylcholine-induced relaxation in rabbit renal arteries. Increased release of nitric oxide and prostacyclin could be responsible for the enhanced relaxant potency of acetylcholine in diabetes.
dc.relation.ispartof European Journal of Pharmacology, 2001, vol. 415, p. 225-232
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Alabadí Ferrer, José Antonio Miranda Alonso, Francisco Javier Lloréns, Silvia Ruiz de Apodaca, Rosa F Centeno Guil, José M Alborch Dominguez, Enrique 2001 Diabetes potentiates acetylcholine-induced relaxation in rabbit renal arteries. European Journal of Pharmacology 415 225 232
dc.subject Òxid nítric
dc.subject Diabetis
dc.subject Endoteli vascular
dc.subject Artèries
dc.title Diabetes potentiates acetylcholine-induced relaxation in rabbit renal arteries
dc.type info:eu-repo/semantics/article
dc.date.updated 2013-12-09T14:07:15Z
dc.identifier.idgrec 021576

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