Experimental diabetes induces hyperreactivity of rabbit renal artery to 5-hydroxytryptamine
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Experimental diabetes induces hyperreactivity of rabbit renal artery to 5-hydroxytryptamine

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Experimental diabetes induces hyperreactivity of rabbit renal artery to 5-hydroxytryptamine

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dc.contributor.author Miranda Alonso, Francisco Javier
dc.contributor.author Alabadí Ferrer, José Antonio
dc.contributor.author Lloréns, Silvia
dc.contributor.author Ruiz de Apodaca, Rosa F.
dc.contributor.author Centeno Guil, José M.
dc.contributor.author Alborch Domínguez, Enrique
dc.date.accessioned 2013-12-09T14:00:50Z
dc.date.available 2013-12-09T14:00:50Z
dc.date.issued 2002
dc.identifier.uri http://hdl.handle.net/10550/32083
dc.description.abstract The influence of diabetes on the response of isolated rabbit renal arteries to 5-hydroxytryptamine (5-HT) was examined. 5-HT induced a concentration-related contraction that was higher in arteries from diabetic rabbits than in arteries from control rabbits. Endothelium removal did not significantly modify 5-HT contractions in arteries from control rabbits but enhanced the response to 5-HT in arteries from diabetic rabbits. Incubation with NG-nitro-L-arginine (L-NA) enhanced contractions to 5-HT in arteries from control and diabetic rabbits. In arteries with endothelium, this L-NA enhancement was lower in diabetic rabbits than in control rabbits. In arteries without endothelium, incubation with L-NA enhanced the maximal contractions to 5-HT in control rabbits but did not in diabetic rabbits. Indomethacin inhibited 5-HT-induced contraction of arteries from control rabbits and enhanced the maximal contraction to 5-HT of arteries from diabetic rabbits. In summary, diabetes enhances contractile response of rabbit renal artery to 5-HT. In control animals, this response is regulated by both endothelial and non-endothelial (neuronal) nitric oxide (NO) and by a vasoconstrictor prostanoid. Diabetes impairs the release of non-endothelial NO and the vasoconstrictor prostanoid
dc.relation.ispartof European Journal of Pharmacology, 2002, vol. 439, p. 121-127
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Miranda Alonso, Francisco Javier Alabadí Ferrer, José Antonio Lloréns, Silvia Ruiz de Apodaca, Rosa F Centeno Guil, José M Alborch Dominguez, Enrique 2002 Experimental diabetes induces hyperreactivity of rabbit renal artery to 5-hydroxytryptamine. European Journal of Pharmacology 439 121 127
dc.subject Diabetis
dc.subject Òxid nítric
dc.subject Endoteli vascular
dc.subject Artèries
dc.title Experimental diabetes induces hyperreactivity of rabbit renal artery to 5-hydroxytryptamine
dc.type info:eu-repo/semantics/article
dc.date.updated 2013-12-09T14:00:50Z
dc.identifier.idgrec 021575

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