Effects of dietary fiber intake on risk factors for cardiovascular disease in subjects at high risk
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Effects of dietary fiber intake on risk factors for cardiovascular disease in subjects at high risk

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Effects of dietary fiber intake on risk factors for cardiovascular disease in subjects at high risk

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dc.contributor.author Estruch, Ramón
dc.contributor.author Martínez-González, Miguel Ángel
dc.contributor.author Corella, Dolores
dc.contributor.author Basora, Josep
dc.contributor.author Ruiz-Gutiérrez, Valentina
dc.contributor.author Covas, María-Isabel
dc.contributor.author Fiol, Miquel
dc.contributor.author Gómez-Gracia, Enrique
dc.contributor.author López-Sabater, M. C.
dc.contributor.author Escoda, R.
dc.contributor.author Pena, M. A.
dc.contributor.author Díez-Espino, Javier
dc.contributor.author Lahoz, C.
dc.contributor.author Lapetra, José
dc.contributor.author Sáez, Guillermo T.
dc.contributor.author Ros Ibarra, Eduardo
dc.date.accessioned 2011-06-02T09:25:29Z
dc.date.available 2011-06-02T09:25:29Z
dc.date.issued 2009
dc.identifier.uri http://hdl.handle.net/10550/18825
dc.description.abstract Background: Epidemiological studies and feeding trials with supplements suggest that fibre intake is associated with a reduction in cardiovascular risk. However, the effects of changes in dietary fibre on risk factor levels have not been evaluated in free-living individuals. Thus, the effects of changes in dietary fibre intake on cardiovascular risk factors were assessed over 3 months in free-living high-risk subjects. Methods: 772 high-risk subjects (age 69±5 years) were assigned to a low-fat diet or two Mediterranean-style diets. All participants received behavioural and nutritional education, including recommendations for increasing the consumption of vegetables, fruits, and legumes. Changes in food and nutrient intake, body weight, blood pressure, lipid profiles, glucose control and inflammatory markers were evaluated. Results: Most participants increased consumption of vegetable products, but the increase in dietary fibre exhibited wide between-subject variability (6–65 g/day). Body weight, waist circumference, and mean systolic and diastolic blood pressure decreased across quintiles of fibre intake (p<0.005; all). Reductions in fasting glucose and total cholesterol levels, and increments in HDL cholesterol were highest among participants in the upper 20% of fibre intake (p = 0.04 and 0.02 respectively). Plasma concentrations of C-reactive protein, but not those of inflammatory cytokines, decreased in parallel with increasing dietary fibre (p = 0.04). Significant reductions in LDL cholesterol were observed only among participants with the greatest increases in soluble fibre intake (p = 0.04). Conclusions: Increasing dietary fibre intake with natural foods is associated with reductions in classical and novel cardiovascular risk factors in a high-risk cohort. en
dc.language.iso en en
dc.relation http://jech.bmj.com/content/63/7/582.full.pdf en
dc.source ESTRUCH, R. ; Martínez-González, M. A. ; Corella Piquer, Maria Dolores ; Basora-Gallisá, J. ; Ruiz-Gutiérrez, V. ; Covas, M. I. ; Fiol, M. ; Gómez-Gracia, E. ; López-Sabater, M. C. ; Escoda, R. ; Pena, M. A. ; Díez-Espino, J. ; Lahoz, C. ; Lapetra, J. ; Sáez, G. ; Ros, E., 2009, Effects of dietary fiber intake on risk factors for cardiovascular disease in subjects at high risk, Journal of Epidemiology and Community Health, vol. 63, no. 7, p. 575-581 en
dc.subject Dietary fiber ; Risk factors ; Cardiovascular disease ; High risk subjects en
dc.title Effects of dietary fiber intake on risk factors for cardiovascular disease in subjects at high risk en
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS ::Salud pública en
dc.identifier.doi 10.1136/jech.2008.082214 en
dc.description.private Corella Piquer, Maria Dolores, Dolores.Corella@uv.es en
dc.identifier.idgrec 057405 en

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