The effect of genetic robustness on evolvability in digital organisms
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The effect of genetic robustness on evolvability in digital organisms

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The effect of genetic robustness on evolvability in digital organisms

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dc.contributor.author Elena Fito, Santiago F.
dc.contributor.author Sanjuán Verdeguer, Rafael
dc.date.accessioned 2010-07-28T12:00:27Z
dc.date.available 2010-07-28T12:00:27Z
dc.date.issued 2008
dc.identifier.uri http://hdl.handle.net/10550/16715
dc.description.abstract Background Recent work has revealed that many biological systems keep functioning in the face of mutations and therefore can be considered genetically robust. However, several issues related to robustness remain poorly understood, such as its implications for evolvability (the ability to produce adaptive evolutionary innovations). Results Here, we use the Avida digital evolution platform to explore the effects of genetic robustness on evolvability. First, we obtained digital organisms with varying levels of robustness by evolving them under combinations of mutation rates and population sizes previously shown to select for different levels of robustness. Then, we assessed the ability of these organisms to adapt to novel environments in a variety of experimental conditions. The data consistently support that, for simple environments, genetic robustness fosters long-term evolvability, whereas, in the short-term, robustness is not beneficial for evolvability but may even be a counterproductive trait. For more complex environments, however, results are less conclusive. Conclusion The finding that the effect of robustness on evolvability is time-dependent is compatible with previous results obtained using RNA folding algorithms and transcriptional regulation models. A likely scenario is that, in the short-term, genetic robustness hampers evolvability because it reduces the intensity of selection, but that, in the long-term, relaxed selection facilitates the accumulation of genetic diversity and thus, promotes evolutionary innovation. en
dc.language.iso en en
dc.relation http://www.biomedcentral.com/content/pdf/1471-2148-8-284.pdf en
dc.source Elena Fito, Santiago; Sanjuan Verdeguer, Rafael. The effect of genetic robustness on evolvability in digital organisms. En BMC Evolutionary Biology 2008, 8:284 en
dc.subject Genetic robustness; Digital organisms; Evolutionary innovations en
dc.title The effect of genetic robustness on evolvability in digital organisms en
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS DE LA VIDA::Otras especialidades de la biología en
dc.identifier.doi 10.1186/1471-2148-8-284 en
dc.description.private elena@uv.es; rasanve2 en
dc.identifier.idgrec 053671 en

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