Cryptochrome-1 expression: a new prognostic marker in B-cell chronic lymphocytic leukemia
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Cryptochrome-1 expression: a new prognostic marker in B-cell chronic lymphocytic leukemia

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Cryptochrome-1 expression: a new prognostic marker in B-cell chronic lymphocytic leukemia

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dc.contributor.author Jantus Lewintre, Eloisa
dc.contributor.author Reinoso Martín, Cristina
dc.contributor.author García Ballesteros, Carlos
dc.contributor.author Montaner González, David
dc.contributor.author Farrás Rivera, Rosa
dc.contributor.author Mayans, José Ramón
dc.contributor.author García-Conde Bru, Javier
dc.date.accessioned 2010-07-28T11:41:00Z
dc.date.available 2010-07-28T11:41:00Z
dc.date.issued 2008
dc.identifier.uri http://hdl.handle.net/10550/16692
dc.description.abstract Chronic lymphocytic leukemia is an adult-onset leukemia with a heterogeneous clinical behavior. When chronic lymphocytic leukemia cases were divided on the basis of IgVH mutational status, widely differing clinical courses were revealed. Since IgVH sequencing is difficult to perform in a routine diagnostic laboratory, finding a surrogate for IgVH mutational status seems an important priority. In the present study, we proposed the use of Cryptochrome- 1 as a new prognostic marker in early-stage chronic lymphocytic leukemia. Seventy patients (Binet stage A, without treatment) were included in the study. We correlated Cryptochrome-1 mRNA with well established prognostic markers such as IgVH mutations, ZAP70, LPL or CD38 expression and chromosomal abnormalities. High Cryptochrome-1 expression correlated with IgVH unmutated samples. In addition, Cryptochrome-1 was a valuable predictor of disease progression in early stage chronic lymphocytic leukemia, therefore it can be introduced in clinical practice with the advantage of a simplified method of quantification. en
dc.language.iso en en
dc.relation http://www.haematologica.org/cgi/reprint/94/2/280 en
dc.source JANTUS LEWINTRE, Eloisa ; Reinoso Martín, Cristina ; García Ballesteros, Carlos ; Montaner Gonzalez, David ; Farrás Rivera, Rosa ; Mayans, José Ramón ; García-Conde, Javier, 2008, Cryptochrome-1 expression: a new prognostic marker in B-cell chronic lymphocytic leukemia, Haematologica, vol. 94, no. 2, p. 280-284 en
dc.subject Cryptochrome-1 ; Prognostic marker ; Chronic lymphocytic leukemia ; ZAP70, LPL, IgVH en
dc.title Cryptochrome-1 expression: a new prognostic marker in B-cell chronic lymphocytic leukemia en
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS ::Patología::Oncología en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS ::Patología::Hematología
dc.identifier.doi 10.3324/haematol.13052 en
dc.description.private Montaner Gonzalez, David, David.Montaner@uv.es en

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