Candida albicans fibrinogen binding mannoprotein: expression in clinical strains and immunogenicity in patients with candidiasis
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Candida albicans fibrinogen binding mannoprotein: expression in clinical strains and immunogenicity in patients with candidiasis

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Candida albicans fibrinogen binding mannoprotein: expression in clinical strains and immunogenicity in patients with candidiasis

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dc.contributor.author Sepúlveda Sanchis, Pilar
dc.contributor.author López-Ribot, Jose Luis
dc.contributor.author Murgui Faubel, María Amelia
dc.contributor.author Cantón Lacasa, Emilia
dc.contributor.author Navarro Ortega, David
dc.contributor.author Martínez García, José Pedro
dc.date.accessioned 2010-06-03T07:45:49Z
dc.date.available 2010-06-03T07:45:49Z
dc.date.issued 1998
dc.identifier.uri http://hdl.handle.net/10550/12856
dc.description.abstract A 58 kDa cell wall-associated fibrinogen binding mannoprotein (mp58), previously characterized by our group in a Candida albicans laboratory strain (ATCC 26555), was found to be also present in the cell wall of clinical isolates of this fungus. Most strains examined appear to have functional mp58 species, as detected by their ability to bind fibrinogen. Western immunoblot analysis, with a monovalent polyclonal antibody generated against the mp58 species from strain ATCC 26555, revealed differences in recognition patterns depending on the strain tested and the culture conditions used. Serum samples from normal and Candida infected individuals were examined for the presence of antibodies against mp58 by Western immunoblotting. None of the sera from control individuals and patients suffering from superficial candidiasis contained antibodies against mp58. However, positive reactivity with this antigen and other cell wall constituents was detected for all sera from patients with confirmed systemic candidiasis. Together, these results suggest that mp58 could play an active role during infection and may be useful as a specific antigenic marker for candidiasis. en
dc.language.iso en en
dc.relation http://www.im.microbios.org/03setember98/07%20Sepulveda.pdf en
dc.source Sepúlveda Sanchis, Pilar; López-Ribot, José: Murgui Faubel, Maria Amelia; Cantón, Emilia; Navarro Ortega, David; Martinez Garcia, Jose Pedro. Candida albicans fibrinogen binding mannoprotein: expression in clinical strains and immunogenicity in patients with candidiasis. En International Microbiology, 1998, 1:209–216 en
dc.subject Candida albicans; Clinical strains; Cell wall; Fibrinogen-binding mannoprotein ; Serologic response en
dc.title Candida albicans fibrinogen binding mannoprotein: expression in clinical strains and immunogenicity in patients with candidiasis en
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS DE LA VIDA::Microbiología en
dc.description.private sepulves@uv.es; murgui@uv.es; navarrod@uv.es; martinjp@uv.es en

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