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Language Medicina oral, patología oral y cirugía bucal. Ed inglesa. 2025. Vol. 30, no. 06
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- The relationship between periodontitis and proteinuria in chronic kidney disease: a review(2025) Zhu, Guangxun; Chen, Lili; Liu, QianProteinuria is elevated protein in the urine possibly progressing to glomerular sclerosis, which was frequently observed in chronic kidney disease (CKD), diabetes, preeclampsia, etc. Previous studies have revealed that periodontitis and these diseases share common risk factors, so a study is necessary to discuss the potential relationship between periodontitis and proteinuria. For the moment, there are no reports that are concerned about the correlation between periodontitis and proteinuria. We searched PubMed for studies associated with periodontitis and proteinuria published before March 2025. Existing evidence showed that periodontitis might increase the risk of proteinuria, as periodontal pathogens and periodontal inflammatory reactions were proven to injure the glomerulus and renal tubules contributing to the progression of proteinuria. On the other way, proteinuria might affect systemic inflammation and bone metabolism to increase the risk of periodontitis. This article reviews the relationship between periodontitis and proteinuria, reveals their predicTable potential for chronic kidney injury, and makes recommendations for the treatment of periodontitis and proteinuria.
- Identification of actin cytoskeleton organization genes in oral cancer and oral potentially malignant disorders using oral tissue RNA-seq database(2025) Serna García, Marta; Formaggio, Agnese; Carceller Zazo, María del Carmen; Romero, Joaquín Javier Panadero; Flacco, NiclaOral cancer and oral potentially malignant disorders (leukoplakia and oral submucous fibrosis) are prevalent and clinically significant oral diseases. Actin, crucial for epithelial tissue integrity, undergoes cytoskeleton reorganization associated with increased invasiveness in oral cancer. Bioinformatic analysis of RNA-seq data from GEO public databases was performed to detect differentially expressed genes in oral cancer, leukoplakia and oral submucous fibrosis. Enrichment analysis of the differentially expressed genes was performed using DAVID and GSEA software. ROC curve and survival analysis were conducted to assess the discriminative capacity of these genes as possible biomarkers. The results were further validated using RNAseq data from The Cancer Genome Atlas (TCGA). EPRS1 was consistently overexpressed in all three pathologies. Key genes (ACTIN1, LIMK1, CORO1C, INF2, SH3D21, CFL1, FSCN1, MYO1B) implicated in actin cytoskeleton organization were identified, suggesting their role in oral potentially malignant disorders and cancer progression. Receiver operating characteristic (ROC) curves on 522 TCGA samples demonstrated these genes' potential as early biomarkers for oral cancer, with their inhibition associated with improved survival. The identified genes offer insights into actin-related mechanisms and potential pathways for the diagnosis and treatment of oral cancer. Nonetheless, further research is essential to validate these results.
- Effectiveness of zygomatic implants using the externalized technique in the rehabilitation of atrophic maxillae. A systematic review with meta-analysis(2025) Rebelo, Helder Lima; Sales, Pedro Henrique da Hora; Silva, Paulo-Goberlânio-de Barros; Leão, Jair Carneiro; Carvalho, Alessandra de Albuquerque TavaresThe objective of this work is to identify the effectiveness and summarize the scientific evidence of zygomatic implants using the externalized technique, as well as to evaluate the possible complications associated with this technique. The study was registered in PROSPERO (CRD42022330060) and the searches were carried out in 6 databases (PubMed, Cochrane, LILACS, Scopus, Embase and Google Scholar), by two researchers individually. The aggregated data were subjected to statistical analysis using the MedCalc program for the variables: success rate and frequency of complications, using a 95% confidence interval. The risk of bias of the included studies was determined using the Newcastle-Ottawa Scale (NOS) tool. 912 articles were found in the initial search and 15 of them were included in this systematic review. A total of 1555 zygomatic implants and 1865 conventional implants were part of the study, with an overall success rate of 96.7% for zygomatic implants and 97.9% for conventional implants. There was no statistically significant difference between the survival of zygomatic implants using the externalized technique when compared with conventional implants (p=0.015). There was no significant heterogeneity between studies (p=0.89, I²=0%). Regarding complications, the most prevalent were sinusitis, which showed a proportion of 3.028% (CI95% = 1.053, 5.980%) and infections, which showed a proportion of 1.56% (CI95% = 0.358, 3.590%). Only three articles included presented a low risk of bias. Based on the present systematic review and with limited evidence, the use of zygomatic implants using the externalized technique proved to have a high implant success rate and few associated complications for the treatment of atrophic maxillae.
- The effect of dexmedetomidine on perioperative events of orthognathic surgery: a systematic review of randomized controlled trials(2025) Mesquita, Caio Melo; Diniz, Aurélio Carlos; Sakamoto, Silvio Pedro da Silva; Vieira, Walbert-de Andrade; Brito Jr, Rui Barbosa de; Costa, Marcelo Dias Moreira de Assis; Paranhos, Luiz-RenatoOrthognathic surgery is a complex invasive procedure associated with common postoperative symptoms and patient-related events. Dexmedetomidine is an emerging sedative and hypotensive agent that has demonstrated safety and efficacy in perioperative care of other craniofacial procedures. An electronic search was performed in seven primary databases (Cochrane Library, Embase, LILACS, MedLine via PubMed, SciELO, Scopus, and Web of Science) and one additional (EASY) to partially capture the gray literature. The PICO strategy was used to identify randomized clinical trials evaluating the effect of dexmedetomidine on perioperative events in patients undergoing orthognathic surgery compared to placebo or control groups, without restrictions on publication language and year. Two independent reviewers performed data extraction and assessed the risk of bias using the RoB 2.0 tool. The search identified 401 records, of which six studies met the eligibility criteria, including 282 patients from five countries, and published between 2008 and 2023. Outcomes were categorized into six groups based on available data: 1) Airway and Respiratory Events, 2) Emetic Events, 3) Hemodynamic Events, 4) Length of Hospital Stay, 5) Neurological Events, and 6) Pain Burden. Dexmedetomidine reduced coughing and maintained hemodynamic stability but did not prevent emergence agitation. It was associated with lower intraoperative fentanyl use and reduced rescue analgesia requirements. Postoperatively, dexmedetomidine effectively controlled pain, nausea, and vomiting, with significantly lower pain scores and reduced analgesic demand. Among the six studies, only one was classified as high risk of bias due to issues in the randomization process, while the others were categorized as low risk of bias. A meta-analysis was planned but could not be conducted due to high heterogeneity among studies. Dexmedetomidine appears to be a safe and effective option for reducing postoperative symptoms such as pain, nausea, vomiting, and cough in orthognathic surgery, while maintaining hemodynamic stability.
- Comparative study of different kinesiology taping techniques to reduce postoperative morbidity after impacted mandibular third molar surgery(2025) Menziletoglu, Dilek; Guler, Arif Yigit; Esen, AlparslanThe aim of the study was to compare and evaluate the effects of two different kinesio tape techniques on pain, swelling and trismus after mandibular impacted third molar surgery. This study was designed as a controlled, randomized, prospective clinical trial. Mandibular third molars classified as Class II Position B according to Pell and Gregory classification and as mesioangular position according to Winter's classification were extracted. Patients divided into three groups. After third molar surgery, the classical kinesio tape technique (Technique A- kinesio tape which was divided into three equal segments extending from the cheek region to the clavicle) was applied to the patients in Group 1, while new technique (Technique B- both the classical KT extending from the cheek to the clavicle and an additional Y-shaped KT supporting the masseter muscle) was applied to patients in Group 2. No kinesio tape was placed to the patients in Group 3 during the postoperative period. Antibiotic, analgesic and a mouthwash were prescribed to all three groups. Pain was evaluated using with visial analog scale for 7 days postoperatively. Swelling was assessed on the 2nd and 7th postoperative days by taking measurements from five different points using a paper ruler. Maximum mouth opening was recorded using a caliper postoperatively on the second and seventh days. Ninety patients (54 female, 36 male) were included in the study. Pain levels in Group 1 and Group 2 were statistically lower compared to Group 3. Statistical differences were found only on the 2nd and 3rd days between Group 1 and Group 2. The lowest pain level was observed in Group 2. Patients in Group 2 required the least amount of analgesics. Swelling in Group 1 and Group 2 was statistically lower than in Group 3. Statistically significant increases in mouth opening were observed in Group 1 and Group 2 compared to Group 3. No signs of infection were observed in the patients. The results of the quality of life scale indicated that patient satisfaction was highest in Group 2. Although kinesio tape applied with both different techniques was effective in reducing postoperative morbidity, Technique B was more effective.
- Efficacy of leukocyte- and platelet-rich fibrin in the treatment and prevention of medication-related osteonecrosis of the jaw: a prospective study(2025) Medeiros-Monzón, Alejandro; Blanco Carrión, Andrés; Gándara Vila, Pilar; Camolesi, Gisela; Pérez Jardón, Alba; Lorenzo Pouso, Alejandro Ismael; Pérez Sayáns, MarioMedication-related osteonecrosis of the jaws (MRONJ) is a serious condition associated with bone modifying agents (BMAs) intake, leading to impaired bone healing and increased morbidity. Despite various therapeutic approaches, an optimal treatment strategy remains elusive. Leukocyte- and Platelet- Rich fibrin (L-PRF) has emerged as a promising autologous biomaterial due to its regenerative properties. This study aimed to evaluate the efficacy of L-PRF in the treatment and prevention of MRONJ. A prospective cohort study was conducted, including a total of 30 patients diagnosed with MRONJ (stage I or II) or at risk of developing it (non-MRONJ). Patient underwent standardized treatment involving surgical debridement followed by L-PRF application. Clinical and demographic data were collected, and healing outcomes were assessed at multiple follow-up intervals (7 days, 14 days, 1 month, 3 months and 6 months). Statistical analyses, including Kaplan-Meier survival estimates, were performed to evaluate treatment effectiveness. The study demonstrated an overall healing of 90%, with a complete recovery in 82.4% of confirmed MRONJ cases and 100% of at-risk patients. L-PRF exhibited good clinical outcomes, including reduced inflammation and pain, accelerated epithelialization, and improved tissue regeneration. The median healing time was estimated at 33.41 days for MRONJ patients and 11.00 for non-MRONJ. No significant differences in healing rates were observed based on age, sex, or systemic conditions. L-PRF represents a promising adjunct in MRONJ management, improving healing outcomes and postoperative recovery. Its autologous nature and growth factor release enhance bone regeneration, suggesting its potential as both a therapeutic and preventive strategy. Further larger-scale clinical trials are needed to standardize protocols and validate long-term efficacy.
- Comparison between different intermaxillary fixation systems in the surgical and orthopedic treatment of non-condylar mandibular fractures. Systematic review(2025) Mancilla, María José Flores; Arqueros-Lemus, Marcelo; Tapia Contreras, PedroThe treatment of mandibular fractures can be orthopedic and/or surgical; in both modalities, intermaxillary fixation is a therapeutic tool that allows for the stabilization and reduction of fractures, guiding dental occlusion There are different methods of intermaxillary fixation, each with individual characteristics that provide therapeutic options for the practitioner. This study aims to perform a quantitative and qualitative comparison of different features of these intermaxillary fixation systems through a systematic review. A systematic review was performed, following the PRISMA guidelines. The Pubmed, SCOPUS, Web of Science and Cochrane databases were searched. Several variables were considered and are presented comprehensively in Tables and Figures. The initial literature search resulted in 51 articles, of which 9 met the inclusion criteria for the analysis. Of the 51 identified articles, 28 were analyzed, with 19 excluded after full-text evaluation. Ultimately, 9 studies with 3,221 patients were included, comparing Erich arch bars (EAB), hybrid arch bars (HAB), and intermaxillary fixation screws (IMFS). Discussion: The studies focused on simple fractures with sufficient teeth for orthopedic treatment, excluding isolated maxillary fractures. Results showed differences in installation time, occlusal stability, oral hygiene, and costs, with EAB being the most expensive. Patient quality of life and complications, such as screw loss and root perforations, were also evaluated. Most studies presented a low risk of bias. Screw-based methods like IMFS and HAB offer shorter installation times than EAB, reducing surgery duration, costs, and biosecurity risks. While EAB remains a valid option, screw methods provide advantages in time, hygiene control, and biosecurity, with the choice depending on patient needs and surgical experience.
- Quality of life after third molar surgery: a bibliometric analysis of randomized clinical trials(2025) Maferano, Eduardo Frederico Eduardo; Júnior, José Lima Silva; Rodrigues-Ribeiro, Thyciana; Martins Filho, Paulo R.; Silva, Paulo-Goberlânio-de Barros; Granville-Garcia, Ana Flávia; Costa, Fabio Wildson GurgelThis study aimed to conduct a bibliometric analysis of randomized controlled trials (RCTs) that evaluated quality of life following third molar surgery. A bibliometric analysis was performed in accordance with the BIBLIO checklist across 11 databases: Web of Science, MEDLINE, EMBASE, CINAHL, PsycINFO, The Cochrane Library, Livivo, LILACS, Scopus, Epistemonikos, and Google Scholar. RCTs that assessed quality of life after third molar surgery were included. Searches were conducted on September 20, 2024, and updated on May 5, 2025. The initial search retrieved 4,217 records, of which 46 articles were included. The average annual number of publications between 2008 and 2024 was 2.7. A total of 192 authors contributed to the included studies, with the University of Mosul being the most productive institution. India and Iraq were the most prolific countries, each contributing five publications. Most articles were published in journals specializing in oral and maxillofacial surgery. The terms extracted from the titles co-occurrence analysis revealed distinct thematic clusters. Scientific output on quality of life following third molar surgery has shown consistent growth. Future RCTs are encouraged to incorporate qualitative approaches to gain a broader understanding of the clinical and social impacts of surgical interventions.
- Exploring potential salivary biomarkers for dental caries: a systematic review(2025) López Galindo, Mónica Paula; Atashkadeh, WilliamDental caries remains one of the most widespread non-communicable diseases. Saliva is crucial for maintaining oral health as it shields teeth from demineralization and promotes the remineralization of enamel. Although ongoing studies are investigating the relationship between various salivary proteins and dental caries, consensus in existing literature has not yet been established. This study aims to provide additional insights into the current research of salivary protein biomarkers association with dental caries. This systematic review analyzed literature published between January 2013 to December 2023, retrieved from PubMed, Scopus, and Web of Science. The review included 21 observational studies (2 cohort, 2 case-control, and 17 cross-sectional) involving over 2,000 participants, examining 18 different proteins. There was considerable variability in the types of salivary markers studied. Among the participants, 54% were diagnosed as caries-active (CA), while 45.9% were caries-free (CF), with ages ranging from 6 to 89 years. The Newcastle-Ottawa Scale indicated that the risk of bias was low in 10 studies, intermediate in 10, and high in 1. Eighteen studies found significant differences in protein expression between CA and CF subjects, underscoring the potential of using salivary biomarkers for non-invasive diagnose assessment. However, larger and greater designed studies are needed to establish their clinical value. Besides, divergent results from proteomic studies on biomarkers may be due to variations in genetics, diet, oral hygiene, age and other factors of the subjects, which could affect the reliability of saliva biomarkers in caries screening and detection. The significant heterogeneity among studies made conducting a proper meta-analysis infeasible.
- Radiological features of double and inverted mesiodens: a systematic review of the literature and presentation of two cases(2025) Lo-Casto, Antonio; Panzarella, Vera; Palizzolo, Ettore; Mauceri, Rodolfo; Giuliana, Giovanna; Bencivinni, Francesco; La-Mantia, Gaetano; Campisi, Giuseppina; De-Angelis, Manfredi; La-Tona, Giuseppe; Di Fede, OlgaMesiodens are the most prevalent supernumerary teeth, defined as a dentition anomaly. Mesiodens account for 80% of all supernumerary teeth, with a prevalence in the general population of 0.15% -1.9%. Mesiodens show a higher frequency in man than in women, it is usually found in the front upper jaw, between the midlines of maxillary central teeth. It may be normally oriented or have inverted and transverse orientation. Single or multiple mesiodens may occur; however, double mesiodens is rarer (10-19% of all patients with mesiodens), and even rarer is its double inversion, with the crown and root oriented towards the nasal and oral cavities. The aim of this study is to investigate the main cone-beam computed tomography (CBCT) radiological features of patients affected by mesiodens. Two cases of double mesiodens, one of which with double inversion, in pediatric patients are reported. According to PRISMA guidelines, a systematic review search was conducted on PubMed, Scopus, and Web of Science. Observational studies conducted on patients with double mesiodens were selected and analyzed, including both radiological features and clinical characteristics. Furthermore, two cases of patients with double mesiodens were reported. Fourteen studies were included, and 14 patients affected by double mesiodens were analyzed (12 males, 2 females, with a mean age of 13.5 ± 6.4 years). The present study underscores the importance of considering the CBCT a fundamental investigation to define and appropriate diagnosis and management, and to avoid complications related to a late diagnosis and/or an unnecessary surgical approach.
- Antimicrobial activity of piperacillin/tazobactam against key peri-implant pathogens: an in vitro comparative study with amoxicillin-clavulanate and minocycline(2025) Hurtado Celotti, Dolores; Andrés Veiga, María; Madrigal Martínez-Pereda, Cristina; Meniz García, Cristina; Santos Marino, Juan Antonio; Martínez Rodríguez, NataliaPeri-implantitis is an inflammatory disease linked to bacterial biofilms that threatens the long-term success of dental implants. The growing problem of antibiotic resistance among peri-implant pathogens highlights the need to explore alternative antimicrobial agents with proven in vitro efficacy. This in vitro study evaluated the antimicrobial activity of piperacillin/tazobactam compared with two commonly used antibiotics in dentistry: amoxicillin-clavulanate and minocycline. The minimum inhibitory concentrations (MICs) were determined using Etest® gradient diffusion strips against three key peri-implant pathogens: Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans. Cultures were incubated under anaerobic conditions to simulate the peri-implant environment. Piperacillin/tazobactam demonstrated MIC values comparable to those of amoxicillin-clavulanate and minocycline for P. gingivalis and A. actinomycetemcomitans, and lower MICs against P. intermedia. Statistical analysis confirmed that piperacillin/tazobactam is not inferior to these widely used antibiotics. Piperacillin/tazobactam shows promising in vitro antimicrobial activity against key peri-implant pathogens and may serve as an effective alternative or adjunctive treatment in managing peri-implantitis. Further clinical studies are warranted to confirm its efficacy and safety in vivo.
- Oral Medicine: a retrospective analysis of patient profiles, diagnoses, and referral patterns in Mexico City(2025) Figueroa-Ramos, Alexia Mariana; Saavedra, Gabriela Anaya; Irigoyen Camacho, María Esther; Mosqueda Taylor, AdalbertoOral Medicine (OM) is a dental specialty dedicated to diagnosing and non-surgical managing of oral diseases, often in medically compromised patients. In Mexico, no prior studies have examined the scope of the clinical practice of this specialty; thus, this study aims to examine the characteristics of patients treated at three different reference centers of OM in Mexico City, focusing on their diagnoses, sources of referral, and treatments. This retrospective, observational and descriptive study reviewed 1,270 clinical records from three specialized OM centers between 2015 and 2022: a university clinic, an intrahospital service and a private OM practice. Demographic, clinical and therapeutic data were collected and analyzed using JMP Pro 16, with a significance level of p <0.05. Most patients were women (71.6%), primarily in their sixth and seventh decades of life. Comorbidities were present in 74.7% of cases, and 63.2% of patients were on medications. In public institutions, the most frequent reason for consultation were tumors, while in the private clinic, it was burning mouth. Dentists were the main referrers (49%), yet only 24.2% of referrals included a diagnosis, of which 60% were accurate. The most prevalent oral conditions were non-odontogenic infections (26.4%), ulcerative and vesiculobullous lesions (15.2%), and oral potentially malignant disorders (14.8%). Pharmacologic treatment was provided to 71% of patients, while management of 29.9% included consultation with other specialists. This study highlights significant differences in patient profiles, diagnosis, and referral accuracy between the public and private services of OM. The low diagnostic precision in medical and dental referrals underscores the need to strengthen OM education. Additionally, the wide spectrum of oral and maxillofacial disorders and their treatments emphasize the importance of multidisciplinary management and integration with other medical specialties. These findings support the need to evaluate educational programs, optimize referral pathways, and improve the quality of OM care in Mexico.
- Profile and satisfaction of oral pathology/medicine postgraduates: a national multicenter study(2025) Ferreira, Luiz Miguel; Maia-Lima, Marcos Paulo; Trezena, Samuel; Nascimento, João Pedro Santos; de Oliveira, Fabrício Emanuel Soares; Sousa, Árlen Almeida Duarte de; Martelli, Daniela Reis Barbosa; Alves, Fabio A.; Freitas, Roseana A.; dos Santos, Jean Nunes; Aguiar, Maria Cássia Ferreira; Lopes, Márcio Ajudarte; Bonan, Paulo Rogério; Almeida, Janete Dias; Martelli Júnior, HercílioThis study aimed to evaluate the profile and professional satisfaction of postgraduate students in Oral Pathology (OP) and Oral Medicine (OM) enrolled in Stricto sensu programs across various Brazilian institutions. A cross-sectional, multicenter study surveyed 139 students from seven universities using a digital questionnaire with 29 questions on sociodemographic, motivations, and satisfaction. Data collection occurred between August and October 2024. Most participants were female (63.3%), aged between 25 and 30 years (59.7%), and enrolled in doctoral programs (55.4%). The most important reasons for pursuing postgraduate studies were knowledge enhancement (86.3%), personal satisfaction (84.9%), and financial factors (51.1%). Despite high satisfaction with their programs, and most of them (64%) feeling prepared for the job market, many students felt that job opportunities in OP/OM were limited. Older students reported greater satisfaction with the program (p = 0.020). Ethnicity influenced satisfaction with the pedagogical project (p < 0.001). Students with partners were more satisfied with the accessibility of the faculty (p = 0.004), as were those with children (p < 0.001). Job prospects were associated with satisfaction in several aspects, including the program (p < 0.001), the pedagogical project (p < 0.001) and the physical infrastructure (p = 0.034). Demographic factors and personal perspectives were associated with students' satisfaction with their postgraduate programs. Addressing employment opportunities and improving program infrastructures, pedagogical projects, and access to advisors/professors could further enhance students' satisfaction and career outcomes in OP/OM.
- Epidemiological evolution of gingival cancer in Spain from 2001 to 2022: a longitudinal study(2025) Celis-Dooner, Jorge; Mateo-Sidrón-Antón, María Cristina; Cerero Lapiedra, Rocío; Moreno López, Luis AlbertoOver the past decades, the literature has described epidemiological changes in oral cancer. However, few updated studies specifically address this issue, particularly those examining it separately from pharyngeal cancer. Some authors suggest gingival cancer is the only intraoral cancer with a higher prevalence among women. A retrospective longitudinal study was conducted using the Specialized Care Activity Registry from the Minimum Basic Data Set to obtain data on gingival cancer patients in Spain from 2001 to 2022. Data from 5,749 patients showed 51.8% were men and 48.2% women. A final predominance in women was observed. The average recorded age was 68.3 years, increasing in both sexes over time. A low frequency of tobacco and alcohol consumption was noted. The age-adjusted incidence was 0.61, with a convergence between sexes due to increased female incidence. During the study period, a reversal in the male-to-female ratio was observed, along with an increase in recorded age, a preference for the mandible over the maxilla, low tobacco and alcohol consumption, and incidence convergence between sexes due to rising female cases.
- Tooth regeneration in animals. A systematic review(2025) Bartolomé Lechuga, José; Hernando Calzado, Lucía; Cobo Vázquez, Carlos; Sanz Alonso, Javier; López-Quiles Martínez, Juan; Madrigal Martínez-Pereda, CristinaMethods for creating bioengineered replacement teeth benefit from a detailed understanding of the molecular signaling networks that regulate the development of natural teeth. In oral and craniofacial research, spheroid cultures have been explored, various studies on organoids, such as those of salivary glands, taste buds, and teeth, are being conducted. The aim of this review is to provide a comprehensive overview of the current knowledge on dental regeneration. This review was registered in PROSPERO (CRD 646053) ad performed following PRISMA guidelines. An electronic search was conducted following the PICO question “In animals (P) subjected to bioengineering techniques (I), is successful dental regeneration achieved (O)?” For evaluating risk of bias, the Arrive scale and the JBI adapted for Quasi-experimental studies tools were used. A total of 83 articles on dental regeneration from the past 5 years were reviewed, and 4 articles that met the selection criteria were included. The studies describe complete dental regeneration in animal models by stimulating genes such as Wnt10a, Bmp6, Grem2a and the identification of genes and antibodies influencing BMP and Wnt signaling pathways (Sox-2), as well as the expression of key factors such as FGF. The development of signaling pathways in dental formation has advanced, yet many uncertainties persist, particularly in the regeneration of complete teeth. Despite progress with animal models and genetic editing, identifying suiTable cellular sources and understanding the key genes involved remain essential for future clinical applications.
- Evolution of oral and oropharyngeal cancer in the Basque Country (Spain) from 1986-1994 to 2012-2017(2025) Amezaga-Fernandez, Iñaut; Marichalar Mendia, Xabier; Lafuente Ibáñez de Mendoza, Irene; López de Munain Marques, Arantza; Aguirre Urizar, José ManuelThe Basque Country (Spain) is one of the European regions with the highest incidence of oral and oropharyngeal cancer, which still shows an unacceptably poor prognosis. The aim of this study was to update the epidemiological and prognostic data on oral cancer in the Basque Country and to analyse its evolution with respect to a previous study carried out in 1986-1994. This retrospective study included all cases diagnosed with oral and oropharyngeal cancer in the Basque Country from 2012 to 2017, obtained from the Cancer Population Registry. Descriptive analysis of the epidemiological data on oral-oropharyngeal cancer and survival analysis of oral squamous cell carcinoma were performed. A total of 1,762 cases of oral-oropharyngeal cancer were analysed. The crude incidence was 7.21 cases in women and 18.07 in men. We recognised an increase in females, older patients and gingival neoplasms. Squamous cell carcinomas accounted for 92.6% of the tumours, with 70.4% affecting males, 91.8% living in urban areas, and 50.2% diagnosed at advanced stages. The overall 5-year survival rate for oral-oropharyngeal cancer in the Basque Country was 50.2%. Oral and oropharyngeal cancer incidence in the Basque Country has decreased overall, although it shows a progressive increase in women, older people and tumours located in the gingiva. The prognosis of oral cancer in the Basque Country is still very poor, thus it is necessary to implement specific preventive and diagnostic protocols to improve it.
- Vascular complications related to Le Fort I osteotomy: a scoping review(2025) Alves, Luiza Clertiani; Alves, Joana Maria; Soares, Ariana Maria; Gondim, Delane V.Le Fort I (LFI) osteotomy represents a secure procedure employed for correcting facial deformities and may be coupled with other facial osteotomies. However, notwithstanding professional proficiency, this technique is not exempt from issues or morbidities. Therefore, the objective of this study was to relate the types of vascular complications associated with LFI. A scoping review was conducted with published articles up to April 2024 sourced from PubMed, LILACS, EMBASE, Scopus, Web of Science, Cochrane Library and Google Scholar. The analyzed data comprised: i) comprehensive details pertaining to each vascular lesion associated with LFI; and ii) pertinent anatomical characteristics along with their implications. A total of 2,415 papers were identified. After removing duplicates and applying the inclusion and exclusion criteria, 33 studies were selected. All included patients had dentofacial deformities. The observed vascular lesions or alterations included: pseudoaneurysm, arteriovenous fistula, section or laceration, maxillary avascular necrosis, internal carotid artery dissection, middle cerebral artery ischemia, and cervicofacial hematoma. Notably, pseudoaneurysm emerged as the most prevalent complication. The surgical features associated with these complications included the incision of the maxillary bone, extending upwards from the pterygomaxillary junction to the pyriform aperture and involving the lateral walls of the nasal cavity. Additionally, disruption of the nasal septum was noted. The internal maxillary artery and its terminal branches are the most exposed to the surgical trauma. Understanding the potential complications, their clinical presentation, diagnostic methodologies, and management options is of paramount importance. Moreover, a multidisciplinary approach is frequently required to effectively address these complexities.
- Influence of implant-supported prosthesis design on peri-implant health: a cross-sectional study(2025) Alahmari, Ahmad; Figueiredo, Rui; García-García, Marta; Mir Mari, Javier; Valmaseda Castellón, E.; Sánchez-Torres, AlbaPeri-implant diseases are common complications that may lead to dental implant failure. An adequate prosthesis design is crucial to reduce the risk of complications, and to improve peri-implant health. The present study was carried out to assess the effect of prosthesis design upon the presence of peri-implant inflammation. A cross-sectional study was conducted in patients with a single-unit implant-supported screw-retained crown. After removing the crowns, standardized photographs were made to assess several variables such as the length of the submucosal extension (SE) or the emergence angle (EA). Clinical signs of inflammation were also registered, and an experienced clinician probed the implants. The White (WES) and Pink Esthetic Scores (PES) were also recorded. Patients were classified into two groups according to the presence (positive bleeding on probing (BoP+)) or absence (negative bleeding on probing (BoP-)) of inflammation around the dental implant. Independent t-tests and one-way ANOVA were used to analyze the data. A total of 90 implants were analyzed. Fifty-two implants (57.8%) had BoP+ while 38 (42.2%) had no signs of inflammation of the peri-implant tissues (BoP-). Long SE was significantly associated with BoP+ sites. The EA did not seem to be related to the presence of inflammation (p=0.642). PES/WES showed a negative correlation with buccal EA (r=-0.227; p=0.032). Long submucosal extensions in single-unit implant-supported crowns seem to be associated with peri-implant tissues inflammation (BoP+). A higher emergence angle on the buccal aspect was associated with poor esthetic outcomes.
