Virus-Host Coevolution as a Tool for Controlling Bacterial Resistance to Phage Therapy
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Virus-Host Coevolution as a Tool for Controlling Bacterial Resistance to Phage Therapy

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Virus-Host Coevolution as a Tool for Controlling Bacterial Resistance to Phage Therapy

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dc.contributor.author Monferrer, Ezequiel
dc.contributor.author Domingo Calap, Pilar
dc.date.accessioned 2020-05-08T09:19:31Z
dc.date.available 2020-05-08T09:19:31Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/10550/74542
dc.description.abstract Bacterial resistance to antibiotics is a global public health concern. New treatments are needed to combat resistant strains, among which phage therapy is a promising option. Probably the main advantages of phage therapy are its high specificity as well as rapid viral adaptability, which in principle allows using phage evolution to overcome resistance. Here, we have performed serial coevolution passages between Escherichia coli and its phage T7 to investigate the ability of coevolved phages to reduce the emergence of resistances. We find that the initial bacterial population is less likely to undergo resistance when challenged with experimentally coevolved phages than when challenged with the wild-type phage. Hence, our findings suggest that coevolved phage preparations could be used to increase the efficacy of phage therapy.
dc.language.iso eng
dc.relation.ispartof Journal of Biotechnology and Biomedicine, 2019, vol. 2, p. 096-104
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Monferrer, Ezequiel Domingo Calap, Pilar 2019 Virus-Host Coevolution as a Tool for Controlling Bacterial Resistance to Phage Therapy Journal of Biotechnology and Biomedicine 2 096 104
dc.subject Bacteriòfags
dc.subject Bacteris patògens
dc.title Virus-Host Coevolution as a Tool for Controlling Bacterial Resistance to Phage Therapy
dc.type info:eu-repo/semantics/article
dc.date.updated 2020-05-08T09:19:32Z
dc.identifier.doi https://doi.org/10.26502/jbb.2642-91280013
dc.identifier.idgrec 138847

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