Stem cell paracrine actions in tissue regeneration and its potential therapeutic effect in human endometrium: a retrospective study.
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Stem cell paracrine actions in tissue regeneration and its potential therapeutic effect in human endometrium: a retrospective study.

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Stem cell paracrine actions in tissue regeneration and its potential therapeutic effect in human endometrium: a retrospective study.

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de Miguel, Lucía; Ferrero, Hortensia; López Martínez, Sara; Campo, Hannes; López Pérez, Nuria; Faus, Amparo; Hervás, David; Santamaría, Xavier; Pellicer, Antonio; Cervelló Alcaraz, Irene
This document is a artículoDate2020
Objective: Determining genetic and paracrine mechanisms behind endometrial regeneration in Asherman's Syndrome and Endometrial Atrophy (AS/EA) patients after autologous CD133+ bone marrow-derived stem cells (CD133+BMDSCs) transplantation. Design: Retrospective study using human endometrial biopsies and mouse models. Setting: Fundación-IVI, IIS-La Fe, Valencia, Spain. Samples: Endometrial biopsies collected before and after CD133+BMDSCs therapy, from 8 women with AS/EA (NCT02144987). And uterus from 5 mice, with only left horns receiving CD133+BMDSCs therapy. Methods: In human samples, hematoxylin and eosin (H&E) staining, RNA arrays, PCR validation and neutrophil elastase (NE) immunohistochemistry (IHQ). In mouse samples, PCR validation and protein immunoarrays.

    de Miguel, Lucía Ferrero, Hortensia López Martínez, Sara Campo, Hannes López Pérez, Nuria Faus, Amparo Hervás, David Santamaría, Xavier Pellicer, Antonio Cervelló Alcaraz, Irene 2020 Stem cell paracrine actions in tissue regeneration and its potential therapeutic effect in human endometrium: a retrospective study. BJOG-An International Journal of Obstetrics and Gynaecology

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