E-Cadherin gene expression in oral cancer : clinical and prospective data
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E-Cadherin gene expression in oral cancer : clinical and prospective data

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E-Cadherin gene expression in oral cancer : clinical and prospective data

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dc.contributor.author López-Verdín, Sandra es
dc.contributor.author Martínez-Fierro, Margarita de la Luz es
dc.contributor.author Garza Veloz, Idalia es
dc.contributor.author Zamora Pérez, Ana Lourdes es
dc.contributor.author Grajeda-Cruz, Jonathan es
dc.contributor.author González González, Rogelio es
dc.contributor.author Molina Frechero, Nelly es
dc.contributor.author Arocena, Miguel es
dc.contributor.author Bologna Molina, Ronell es
dc.date.accessioned 2019-11-06T12:51:17Z
dc.date.available 2019-11-06T12:51:17Z
dc.date.issued 2019 es
dc.identifier.uri https://hdl.handle.net/10550/72056
dc.description.abstract Low protein expression of E-cadherin in oral squamous cell carcinoma (OSCC) has been associated with clinical and histopathological traits such as metastases, recurrence, low survival and poor tumor differentiation, and it is considered a high-risk marker of malignancy. However, it is still unknown whether low expression of E-cadherin is also present at the mRNA level in OSCC cases. Objective: The aim of this study was to compare E-cadherin mRNA expression in OSCC patients and controls and to correlate the expression with clinical and prospective characteristics. Forty patients and 40 controls were enrolled. E-cadherin mRNA expression was evaluated by quantitative real-time polymerase chain reaction using TaqMan probes. E-cadherin mRNA expression was significantly decreased in OSCC patients compared to that of controls (p<0.001). Whereas no significant association between clinical parameters and E-cadherin expression levels was observed, we noted lower E-cadherin expression levels in patients with positive lymph node metastasis. E-cadherin mRNA expression was markedly diminished in OSCC, in agreement with previous results that examined E-cadherin expression at the protein level. E-cadherin is downregulated in the early clinical stages of OSCC, and its mRNA levels do not change significantly in the advanced stages, suggesting that there is limited usefulness of this parameter for predicting disease progression. es
dc.source López-Verdín, Sandra ; Martínez-Fierro, Margarita de la Luz ; Garza Veloz, Idalia ; Zamora Pérez, Ana Lourdes ; Grajeda-Cruz, Jonathan ; González González, Rogelio ; Molina Frechero, Nelly ; Arocena, Miguel ; Bologna Molina, Ronell. E-Cadherin gene expression in oral cancer : clinical and prospective data. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 24 4 2019: 16- es
dc.title E-Cadherin gene expression in oral cancer : clinical and prospective data es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.23029 es

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