Performance of polyester-based electrospun scaffolds under in vitro hydrolytic conditions: From short-term to long-term applications
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Performance of polyester-based electrospun scaffolds under in vitro hydrolytic conditions: From short-term to long-term applications

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Performance of polyester-based electrospun scaffolds under in vitro hydrolytic conditions: From short-term to long-term applications

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dc.contributor.author Gil Castell, O.
dc.contributor.author Badia Valiente, José David
dc.contributor.author Bou, Jordi
dc.contributor.author Ribes Greus, A.
dc.date.accessioned 2019-10-23T14:13:15Z
dc.date.available 2019-10-23T14:13:15Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/10550/71802
dc.description.abstract The evaluation of the performance of polyesters under in vitro physiologic conditions is essential to design scaffolds with an adequate lifespan for a given application. In this line, the degradation-durability patterns of poly(lactide-co-glycolide) (PLGA), polydioxanone (PDO), polycaprolactone (PCL) and polyhydroxybutyrate (PHB) scaffolds were monitored and compared giving, as a result, a basis for the specific design of scaffolds from short-term to long-term applications. For this purpose, they were immersed in ultra-pure water and phosphate buffer solution (PBS) at 37 °C. The scaffolds for short-time applications were PLGA and PDO, in which the molar mass diminished down to 20% in a 20-30 days lifespan. While PDO developed crystallinity that prevented the geometry of the fibres, those of PLGA coalesced and collapsed. The scaffolds for long-term applications were PCL and PHB, in which the molar mass followed a progressive decrease, reaching values of 10% for PCL and almost 50% for PHB after 650 days of immersion. This resistant pattern was mainly ascribed to the stability of the crystalline domains of the fibres, in which the diameters remained almost unaffected. From the perspective of an adequate balance between the durability and degradation, this study may serve technologists as a reference point to design polyester-based scaffolds for biomedical applications.
dc.language.iso eng
dc.relation.ispartof Nanomaterials, 2019, vol. 9, num. 5, p. 786
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Gil Castell, O. Badia Valiente, José David Bou, Jordi Ribes Greus, A. 2019 Performance of polyester-based electrospun scaffolds under in vitro hydrolytic conditions: From short-term to long-term applications Nanomaterials 9 5 786
dc.subject Nanotecnologia
dc.subject Termoplàstics
dc.title Performance of polyester-based electrospun scaffolds under in vitro hydrolytic conditions: From short-term to long-term applications
dc.type info:eu-repo/semantics/article
dc.date.updated 2019-10-23T14:13:15Z
dc.identifier.doi https://doi.org/10.3390/nano9050786
dc.identifier.idgrec 134924

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