The Maternal hormone in the male brain: Sexually dimorphic distribution of prolactin signalling in the mouse brain
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The Maternal hormone in the male brain: Sexually dimorphic distribution of prolactin signalling in the mouse brain

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The Maternal hormone in the male brain: Sexually dimorphic distribution of prolactin signalling in the mouse brain

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dc.contributor.author Salais López, Hugo
dc.contributor.author Agustín-Pavón, Carmen
dc.contributor.author Lanuza Navarro, Enrique
dc.contributor.author Martínez-García, Fernando
dc.date.accessioned 2019-02-28T16:20:25Z
dc.date.available 2019-02-28T16:20:25Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/10550/69210
dc.description.abstract Research of the central actions of prolactin is highly focused on females, but this hormone has also documented roles in male physiology and behaviour. Here, we provide the first description of the pattern of prolactin-derived signalling in the male mouse brain, employing the immunostaining of phosphorylated signal transducer and activator of transcription 5 (pSTAT5) after exogenous prolactin administration. Next, we explore possible sexually dimorphic differences by comparing pSTAT5 immunoreactivity in prolactin-supplemented males and females. We also assess the role of testosterone in the regulation of central prolactin signalling in males by comparing intact with castrated prolactin-supplemented males. Prolactin-supplemented males displayed a widespread pattern of pSTAT5 immunoreactivity, restricted to brain centres showing expression of the prolactin receptor. Immunoreactivity for pSTAT5 was present in several nuclei of the preoptic, anterior and tuberal hypothalamus, as well as in the septofimbrial nucleus or posterodorsal medial amygdala of the telencephalon. Conversely, non-supplemented control males were virtually devoid of pSTAT5-immunoreactivity, suggesting that central prolactin actions in males are limited to situations concurrent with substantial hypophyseal prolactin release (e.g. stress or mating). Furthermore, comparison of prolactin-supplemented males and females revealed a significant, female-biased sexual dimorphism, supporting the view that prolactin has a preeminent role in female physiology and behaviour. Finally, in males, castration significantly reduced pSTAT5 immunoreactivity in some structures, including the paraventricular and ventromedial hypothalamic nuclei and the septofimbrial region, thus indicating a region-specific regulatory role of testosterone over central prolactin signalling.
dc.language.iso eng
dc.relation.ispartof Plos One, 2018, vol. 13, num. 12, p. e0208960
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Salais López, Hugo Agustín-Pavón, Carmen Lanuza Navarro, Enrique Martínez-García, Fernando 2018 The Maternal hormone in the male brain: Sexually dimorphic distribution of prolactin signalling in the mouse brain Plos One 13 12 e0208960
dc.subject Cervell Localització de funcions
dc.subject Hormones esteroides
dc.title The Maternal hormone in the male brain: Sexually dimorphic distribution of prolactin signalling in the mouse brain
dc.type info:eu-repo/semantics/article
dc.date.updated 2019-02-28T16:20:26Z
dc.identifier.doi https://doi.org/10.1371/journal.pone.0208960
dc.identifier.idgrec 130265

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