Detection of human papillomavirus DNA in formalin-fixed, paraffin-embedded squamous papillomas of the oral cavity
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Detection of human papillomavirus DNA in formalin-fixed, paraffin-embedded squamous papillomas of the oral cavity

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Detection of human papillomavirus DNA in formalin-fixed, paraffin-embedded squamous papillomas of the oral cavity

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dc.contributor.author Daigrepont, Jack es
dc.contributor.author Cameron, Jennifer E. es
dc.contributor.author Wright, Kelly L. es
dc.contributor.author Cordell, Kitrina G. es
dc.contributor.author Rosebush, Molly S. es
dc.date.accessioned 2018-11-28T12:52:10Z
dc.date.available 2018-11-28T12:52:10Z
dc.date.issued 2018 es
dc.identifier.uri http://hdl.handle.net/10550/68143
dc.description.abstract Squamous papillomas are exophytic proliferations of surface oral epithelium. Human papillomavirus (HPV) infection is widely accepted as the etiology of squamous papillomas however the virus cannot be detected in a significant percentage of lesions. Using polymerase chain reaction (PCR), we tested 35 formalin-fixed paraffin-embedded (FFPE) squamous papillomas for the presence of HPV DNA. Six papillomas (17%) tested positive for HPV DNA; four contained HPV-6 and two contained HPV-11. Given that ??globin DNA was only identified in half of the samples, DNA degradation appears to have significantly impacted the results. The results likely represent an underestimation of the true number of HPV-positive specimens in our study. Potential explanations for HPV-negative squamous papillomas include transient HPV infection, failure of the experiment to detect HPV if present, or the possibility that some lesions may not result from HPV infection. es
dc.source Daigrepont, Jack ; Cameron, Jennifer E. ; Wright, Kelly L. ; Cordell, Kitrina G. ; Rosebush, Molly S.. Detection of human papillomavirus DNA in formalin-fixed, paraffin-embedded squamous papillomas of the oral cavity. En: Journal of Clinical and Experimental Dentistry, 10 10 2018: 979-983 es
dc.title Detection of human papillomavirus DNA in formalin-fixed, paraffin-embedded squamous papillomas of the oral cavity es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/jced.55187 es

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