Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies
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Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies

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Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies

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dc.contributor.author Catalá López, Ferrán
dc.contributor.author Hutton, Brian
dc.contributor.author Driver, J.A.
dc.contributor.author Page, Matthew J.
dc.contributor.author Ridao, Manuel
dc.contributor.author Valderas, José María
dc.contributor.author Alonso Arroyo, Adolfo
dc.contributor.author Forés Martos, Jaume
dc.contributor.author Martínez, S.
dc.contributor.author Gènova Maleras, Ricard
dc.contributor.author Macías Saint-Gerons, Diego
dc.contributor.author Crespo Facorro, Benedicto
dc.contributor.author Vieta, Eduard
dc.contributor.author Valencia, Alfonso
dc.contributor.author Tabarés Seisdedos, Rafael
dc.date.accessioned 2018-09-03T17:51:14Z
dc.date.available 2018-09-03T17:51:14Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/10550/67384
dc.description.abstract BACKGROUND: The objective of this study will be to synthesize the epidemiological evidence and evaluate the validity of the associations between central nervous system disorders and the risk of developing or dying from cancer. METHODS/DESIGN: We will perform an umbrella review of systematic reviews and conduct updated meta-analyses of observational studies (cohort and case-control) investigating the association between central nervous system disorders and the risk of developing or dying from any cancer or specific types of cancer. Searches involving PubMed/MEDLINE, EMBASE, SCOPUS and Web of Science will be used to identify systematic reviews and meta-analyses of observational studies. In addition, online databases will be checked for observational studies published outside the time frames of previous reviews. Eligible central nervous system disorders will be Alzheimer's disease, anorexia nervosa, amyotrophic lateral sclerosis, autism spectrum disorders, bipolar disorder, depression, Down's syndrome, epilepsy, Huntington's disease, multiple sclerosis, Parkinson's disease and schizophrenia. The primary outcomes will be cancer incidence and cancer mortality in association with a central nervous system disorder. Secondary outcome measures will be site-specific cancer incidence and mortality, respectively. Two reviewers will independently screen references identified by the literature search, as well as potentially relevant full-text articles. Data will be abstracted, and study quality/risk of bias will be appraised by two reviewers independently. Conflicts at all levels of screening and abstraction will be resolved through discussion. Random-effects meta-analyses of primary observational studies will be conducted where appropriate. Parameters for exploring statistical heterogeneity are pre-specified. The World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) criteria and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach will be used for determining the quality of evidence for cancer outcomes. DISCUSSION: Our study will establish the extent of the epidemiological evidence underlying the associations between central nervous system disorders and cancer and will provide a rigorous and updated synthesis of a range of important site-specific cancer outcomes. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42016052762.
dc.language.iso eng
dc.relation.ispartof Systematic Reviews, 2017, num. 6, p. 69-76
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Catalá López, Ferrán Hutton, Brian Driver, J.A. Page, Matthew J. Ridao, Manuel Valderas, José María Alonso Arroyo, Adolfo Forés Martos, Jaume Martínez, S. Gènova Maleras, Ricard Macías Saint Gerons, Diego Crespo Facorro, Benedicto Vieta, Eduard Valencia, Alfonso Tabarés Seisdedos, Rafael 2017 Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies Systematic Reviews 6 69 76
dc.subject Càncer
dc.subject Sistema nerviós central Malalties
dc.subject Anorèxia nerviosa
dc.subject Autisme
dc.subject Esquizofrènia
dc.title Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies
dc.type info:eu-repo/semantics/article
dc.date.updated 2018-09-03T17:51:15Z
dc.identifier.doi https://doi.org/10.1186/s13643-017-0466-y
dc.identifier.idgrec 117657

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