Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva
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Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva

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Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva

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dc.contributor.author López-Verdín, Sandra es
dc.contributor.author Soto-Avila, Juan-José es
dc.contributor.author Zamora Pérez, Ana Lourdes es
dc.contributor.author Lazalde Ramos, Blanca Patricia es
dc.contributor.author Martínez-Fierro, Margarita de la Luz es
dc.contributor.author González González, Rogelio es
dc.contributor.author Molina Frechero, Nelly es
dc.contributor.author Espinoza, Mario Alberto Isiordia es
dc.contributor.author Bologna Molina, Ronell es
dc.date.accessioned 2018-05-02T12:04:11Z
dc.date.available 2018-05-02T12:04:11Z
dc.date.issued 2017 es
dc.identifier.uri http://hdl.handle.net/10550/65937
dc.description.abstract The objective of this study was to assess the potential clinical value of the concentration of soluble salivary E-cadherin (sE-cadherin) compared with the clinical value of the presence of membranous E-cadherin (mE-cadherin) in oral squamous cell carcinoma tumor tissues. Data regarding patient demographics, clinical stage, saliva and tumor tissue samples were collected. The saliva was analyzed for sE-cadherin protein levels and was compared to the mE-cadherin immunohistochemical expression levels in tumor tissues, which were assessed via the HercepTest® method. Patients without cancer were included in the study as a control group for comparisons of the sE-cadherin levels. sE-cadherin levels in the saliva of patients without cancer were lower than those in patients with cancer, and the difference was statistically significant (p=0.031). Low mE-cadherin expression was statistically significantly associated with lymph node positivity (p=0.015) and advanced clinical stage (p=0.001). The inverse relationship between mE-cadherin and sE-cadherin was significant in terms of lymph node positivity (p=0.014) and advanced clinical stage (p=0.037). The results suggest that sE-cadherin levels are significantly increased in patients with oral cancer and that its low expression within the membrane as well as the progression of the disease appear to be inversely associated with levels of sE-cadherin in the saliva. es
dc.source López-Verdín, Sandra ; Soto-Avila, Juan-José ; Zamora Pérez, Ana Lourdes ; Lazalde Ramos, Blanca Patricia ; Martínez-Fierro, Margarita de la Luz ; González González, Rogelio ; Molina Frechero, Nelly ; Espinoza, Mario Alberto Isiordia ; Bologna Molina, Ronell. Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 22 6 2017: 5- es
dc.title Patients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the saliva es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.21907 es

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