Roles of a conserved proline in the internal fusion peptide of Ebola glycoprotein
NAGIOS: RODERIC FUNCIONANDO

Roles of a conserved proline in the internal fusion peptide of Ebola glycoprotein

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Roles of a conserved proline in the internal fusion peptide of Ebola glycoprotein

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Gómara, María J.; Mora, Puig; Mingarro Muñoz, Ismael Perfil; Nieva, José Luis
This document is a artículoDate2004

Este documento está disponible también en : http://hdl.handle.net/10550/65795
The structural determinants underlying the functionality of viral internal fusion peptides (IFPs) are not well understood. We have compared EBOwt (GAAIGLAWIPY- FGPAAE), representing the IFP of the Ebola fusion protein GP, and EBOmut (GAAIGLAWIPYFGRAAE) derived from a non-functional mutant with conserved Pro537 substituted by Arg. P537R substitution did not abrogate peptide-membrane association, but interfered with the ability to induce bilayer destabilization. Structural determinations suggest that Pro537 is required to preserve a membrane-perturbing local conformation in apolar environments.

    Gómara, María J. Mora, Puig Mingarro Muñoz, Ismael Nieva, José Luis 2004 Roles of a conserved proline in the internal fusion peptide of Ebola glycoprotein Febs Letters 569 1-3 261 266
https://doi.org/10.1016/j.febslet.2004.06.006

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