Hexapeptides that interfere with HIV-1 fusion peptide activity in liposomes block GP41-mediated membrane fusion
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Hexapeptides that interfere with HIV-1 fusion peptide activity in liposomes block GP41-mediated membrane fusion

Repositori DSpace/Manakin

Hexapeptides that interfere with HIV-1 fusion peptide activity in liposomes block GP41-mediated membrane fusion

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dc.contributor.author Gómara, María J.
dc.contributor.author Lorizate, Maier
dc.contributor.author Huarte, Nerea
dc.contributor.author Mingarro Muñoz, Ismael
dc.contributor.author Pérez Payá, Enrique
dc.contributor.author Nieva, José Luis
dc.date.accessioned 2018-04-16T13:45:07Z
dc.date.available 2018-04-16T13:45:07Z
dc.date.issued 2006
dc.identifier.uri http://hdl.handle.net/10550/65693
dc.description.abstract Upon receptor-mediated activation, the gp41 hydrophobic, conserved fusion peptide inserts into the target mem- brane and promotes the kind of perturbations required for the progression of the HIV-cell fusion reaction. Using a synthetic combinatorial library we have identified all D-amino acid hexapeptide sequences that inhibited the fusion peptide capacity of perturbing model membranes. Two hexapeptides that effectively inhibited the fusion peptide in these systems were subsequently shown to inhibit cell-cell fusion promoted by gp41 expressed at cell surfaces. These observations might be of importance for understanding the mechanisms underlying fusion peptide activity and suggest new strategies for screening compounds that target these viral sequences.
dc.language.iso eng
dc.relation.ispartof Febs Letters, 2006, vol. 580, num. 11, p. 2561-2566
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Gómara, María J. Lorizate, Maier Huarte, Nerea Mingarro Muñoz, Ismael Pérez Payá, Enrique Nieva, José Luis 2006 Hexapeptides that interfere with HIV-1 fusion peptide activity in liposomes block GP41-mediated membrane fusion Febs Letters 580 11 2561 2566
dc.subject Membranes (Biologia)
dc.subject Pèptids
dc.title Hexapeptides that interfere with HIV-1 fusion peptide activity in liposomes block GP41-mediated membrane fusion
dc.type info:eu-repo/semantics/article
dc.date.updated 2018-04-16T13:45:07Z
dc.identifier.doi https://doi.org/10.1016/j.febslet.2006.04.003
dc.identifier.idgrec 027417

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