Hexapeptides that interfere with HIV-1 fusion peptide activity in liposomes block GP41-mediated membrane fusion
NAGIOS: RODERIC FUNCIONANDO

Hexapeptides that interfere with HIV-1 fusion peptide activity in liposomes block GP41-mediated membrane fusion

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Hexapeptides that interfere with HIV-1 fusion peptide activity in liposomes block GP41-mediated membrane fusion

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Gómara, María J.; Lorizate, Maier; Huarte, Nerea; Mingarro Muñoz, Ismael Perfil; Pérez Payá, Enrique; Nieva, José Luis
This document is a artículoDate2006
Upon receptor-mediated activation, the gp41 hydrophobic, conserved fusion peptide inserts into the target mem- brane and promotes the kind of perturbations required for the progression of the HIV-cell fusion reaction. Using a synthetic combinatorial library we have identified all D-amino acid hexapeptide sequences that inhibited the fusion peptide capacity of perturbing model membranes. Two hexapeptides that effectively inhibited the fusion peptide in these systems were subsequently shown to inhibit cell-cell fusion promoted by gp41 expressed at cell surfaces. These observations might be of importance for understanding the mechanisms underlying fusion peptide activity and suggest new strategies for screening compounds that target these viral sequences.

    Gómara, María J. Lorizate, Maier Huarte, Nerea Mingarro Muñoz, Ismael Pérez Payá, Enrique Nieva, José Luis 2006 Hexapeptides that interfere with HIV-1 fusion peptide activity in liposomes block GP41-mediated membrane fusion Febs Letters 580 11 2561 2566
https://doi.org/10.1016/j.febslet.2006.04.003
distribuido bajo licencia Creative Commons de Reconocimiento-NoComercial 3.0 No adaptada

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