Calcium-dependent conformational changes of membrane-bound Ebola fusion peptide drive vesicle fusion
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Calcium-dependent conformational changes of membrane-bound Ebola fusion peptide drive vesicle fusion

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Calcium-dependent conformational changes of membrane-bound Ebola fusion peptide drive vesicle fusion

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dc.contributor.author Suárez, Tatiana
dc.contributor.author Gómara, María J.
dc.contributor.author Goñi, Félix M.
dc.contributor.author Mingarro Muñoz, Ismael
dc.contributor.author Muga, Arturo
dc.contributor.author Pérez Payá, Enrique
dc.contributor.author Nieva, José Luis
dc.date.accessioned 2018-04-11T14:30:50Z
dc.date.available 2018-04-11T14:30:50Z
dc.date.issued 2003
dc.identifier.uri http://hdl.handle.net/10550/65590
dc.description.abstract The fusogenic subdomain of the Ebola virus envelope glycoprotein is an internal sequence located ca. 20 residues downstream the N‐terminus of the glycoprotein transmembrane subunit. Partitioning of the Ebola fusion peptide into membranes containing phosphatidylinositol in the absence of Ca2+ stabilizes an α‐helical conformation, and gives rise to vesicle efflux but not vesicle fusion. In the presence of millimolar Ca2+ the membrane‐bound peptide adopts an extended β‐structure, and induces inter‐vesicle mixing of lipids. The peptide conformational polymorphism may be related to the flexibility of the virus-cell intermembrane fusogenic complex.
dc.language.iso eng
dc.relation.ispartof Febs Letters, 2003, vol. 535, num. 1-3, p. 23-28
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Suárez, Tatiana Gómara, María J. Goñi, Félix M. Mingarro Muñoz, Ismael Muga, Arturo Pérez Payá, Enrique Nieva, José Luis 2003 Calcium-dependent conformational changes of membrane-bound Ebola fusion peptide drive vesicle fusion Febs Letters 535 1-3 23 28
dc.subject Membranes (Biologia)
dc.subject Pèptids
dc.title Calcium-dependent conformational changes of membrane-bound Ebola fusion peptide drive vesicle fusion
dc.type info:eu-repo/semantics/article
dc.date.updated 2018-04-11T14:30:50Z
dc.identifier.doi https://doi.org/10.1016/S0014-5793(02)03847-4
dc.identifier.idgrec 005271

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