Changes in crevicular cytokines after application of melatonin in patients with periodontal disease
NAGIOS: RODERIC FUNCIONANDO

Changes in crevicular cytokines after application of melatonin in patients with periodontal disease

DSpace Repository

Changes in crevicular cytokines after application of melatonin in patients with periodontal disease

Show simple item record

dc.contributor.author Montero Martín, Javier es
dc.contributor.author López Valverde, Nansi es
dc.contributor.author Ferrera, María José es
dc.contributor.author López-Valverde Centeno, Antonio es
dc.date.accessioned 2017-11-28T11:04:52Z
dc.date.available 2017-11-28T11:04:52Z
dc.date.issued 2017 es
dc.identifier.uri http://hdl.handle.net/10550/63366
dc.description.abstract A clinical trial was designed to evaluate the effects of topical application of melatonin on the crevicular fluid levels of interleukins and prostaglandins and to evaluate changes in clinical parameters. A consecutive sample of 90 patients were recruited from the Health Centre of Pinos Puente in Granada, Spain and divided into 3 groups: 30 patients with diabetes and periodontal disease, who were given melatonin; 30 patients with diabetes and periodontal disease, who were given a placebo, and 30 healthy individuals with no history of systemic disease or clinical signs of periodontal disease, who were also given a placebo. The 30 patients with diabetes and periodontitis were treated with topical application of melatonin (1% orabase cream formula) for 20 days by. The rest of the patients with diabetes and periodontitis and healthy subjects were treated with a placebo of orabase cream. We measured the gingival index by exploring the percentage of standing teeth bleeding on probing. The periodontogram was performed with a Florida Probe. In the diabetic patients who were given topical melatonin, there was a statistically significant decrease in the two clinical parameters. By contrast, in diabetic patients who were given the topical placebo, there was no statistically significant variation. In patients with diabetes and periodontal disease, treatment with topical melatonin was associated with a significant improvement in the gingival index and in pocket depth, and a statistically significant reduction in concentrations of interleukin-1?, interleukin-6 and prostaglandin E2 in gingival crevicular fluid. es
dc.source Montero Martín, Javier ; López Valverde, Nansi ; Ferrera, María José ; López-Valverde Centeno, Antonio. Changes in crevicular cytokines after application of melatonin in patients with periodontal disease. En: Journal of Clinical and Experimental Dentistry, 9 9 2017: 1081-1087 es
dc.title Changes in crevicular cytokines after application of melatonin in patients with periodontal disease es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/jced.53934 es

View       (550.8Kb)

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search

Browse

Statistics