Synthesis and antibacterial activities of cadiolides A, B and C and analogues
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Synthesis and antibacterial activities of cadiolides A, B and C and analogues

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Synthesis and antibacterial activities of cadiolides A, B and C and analogues

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dc.contributor.author Boulangé, Agathe
dc.contributor.author Párraga Vidal, Javier
dc.contributor.author Galán Morant, Abraham
dc.contributor.author Cabedo Escrig, Nuria
dc.contributor.author Leleu, Stéphane
dc.contributor.author Sanz Ferrando, María Jesús
dc.contributor.author Cortés Martínez, Diego M.
dc.contributor.author Franck, Xavier
dc.date.accessioned 2017-11-20T13:48:53Z
dc.date.available 2017-11-20T13:48:53Z
dc.date.issued 2015
dc.identifier.uri http://hdl.handle.net/10550/63166
dc.description.abstract The one-pot multicomponent synthesis of natural butenolides named cadiolides A, B, C and analogues has been realized. The antibacterial structure activity relationship shows that the presence of phenolic hydroxyl groups and the number and position of bromine atoms on the different aromatic rings are important features for antibacterial activity, besides it was demonstrated the tolerance of both benzene and furan ring at position 3 of the butenolide nucleus. Furthermore, none of the most relevant antibacterial compounds showed any cytotoxicity in freshly isolated human neutrophils.
dc.language.iso eng
dc.relation.ispartof Bioorganic & Medicinal Chemistry, 2015, vol. 23, num. 13, p. 3618-3628
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Boulangé, Agathe Párraga Vidal, Javier Galán Morant, Abraham Cabedo Escrig, Nuria Leleu, Stéphane Sanz Ferrando, María Jesús Cortés Martínez, Diego M. Franck, Xavier 2015 Synthesis and antibacterial activities of cadiolides A, B and C and analogues Bioorganic & Medicinal Chemistry 23 13 3618 3628
dc.subject Farmacologia
dc.subject Compostos orgànics Síntesi
dc.title Synthesis and antibacterial activities of cadiolides A, B and C and analogues
dc.type info:eu-repo/semantics/article
dc.date.updated 2017-11-20T13:48:54Z
dc.identifier.doi https://doi.org/10.1016/j.bmc.2015.04.010
dc.identifier.idgrec 108909

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