Synthesis and antibacterial activities of cadiolides A, B and C and analogues
NAGIOS: RODERIC FUNCIONANDO

Synthesis and antibacterial activities of cadiolides A, B and C and analogues

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Synthesis and antibacterial activities of cadiolides A, B and C and analogues

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Boulangé, Agathe; Párraga Vidal, Javier; Galán Morant, Abraham; Cabedo Escrig, Nuria; Leleu, Stéphane; Sanz Ferrando, María Jesús; Cortés Martínez, Diego M.; Franck, Xavier
This document is a artículoDate2015

Este documento está disponible también en : http://hdl.handle.net/10550/63166
The one-pot multicomponent synthesis of natural butenolides named cadiolides A, B, C and analogues has been realized. The antibacterial structure activity relationship shows that the presence of phenolic hydroxyl groups and the number and position of bromine atoms on the different aromatic rings are important features for antibacterial activity, besides it was demonstrated the tolerance of both benzene and furan ring at position 3 of the butenolide nucleus. Furthermore, none of the most relevant antibacterial compounds showed any cytotoxicity in freshly isolated human neutrophils.

    Boulangé, Agathe Párraga Vidal, Javier Galán Morant, Abraham Cabedo Escrig, Nuria Leleu, Stéphane Sanz Ferrando, María Jesús Cortés Martínez, Diego M. Franck, Xavier 2015 Synthesis and antibacterial activities of cadiolides A, B and C and analogues Bioorganic & Medicinal Chemistry 23 13 3618 3628
https://doi.org/10.1016/j.bmc.2015.04.010

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