Effects of polyglecaprone 25, silk and catgut suture materials on oral mucosa wound healing in diabetic rats : an evaluation of nitric oxide dynamics
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Effects of polyglecaprone 25, silk and catgut suture materials on oral mucosa wound healing in diabetic rats : an evaluation of nitric oxide dynamics

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Effects of polyglecaprone 25, silk and catgut suture materials on oral mucosa wound healing in diabetic rats : an evaluation of nitric oxide dynamics

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dc.contributor.author Yilmaz, Nergiz es
dc.contributor.author Inal, Samet es
dc.contributor.author Muglali, Mehtap es
dc.contributor.author Guvenc, Tolga es
dc.contributor.author Bas, Burcu es
dc.date.accessioned 2017-07-27T08:44:13Z
dc.date.available 2017-07-27T08:44:13Z
dc.date.issued 2010 es
dc.identifier.uri http://hdl.handle.net/10550/60358
dc.description.abstract Objectives: The purpose of this study is to investigate the effects of monocryl (Polyglecaprone 25), silk and catgut suture materials on wound healing in diabetic rats and to evaluate NO (nitric oxide) dynamics. Study desing: Fourty-eight male Wistar-Albino rats weighting 220-270 g were used in this study. The rats were categorized into 2 groups, as control group (n=24) and streptozotocin (STZ) induced diabetic group (n=24). For each group, incision wounds were created on the inner cheeck mucosa of the animals and wounds were closed primarily with three different types of sutures. These materials were sized 3-0 monocryl (polyglecaprone 25), silk and catgut sutures swaged on. Excisional biopsies were performed at 2nd, 7th, 14th and 21st day (2 rats per day) from the initial surgical procedure. Effects of these suture materials on wound healing and NOS (nitric oxide synthase) activities were compared immunohistochemically in the study. eNOS and iNOS (Endothelial and induced nitric oxide synthase) activities were classified as mild (+), moderate (++) and severe (+++). Results: Mild eNOS activities were seen in both diabetic and control groups at 2nd day specimens. Activities of silk and catgut were similar both in diabetic and control groups at 14th day, this activity in monocryl was mild. 21st day specimens revealed that monocryl has mild eNOS activity than silk and catgut sutures. iNOS activities in diabetic group were greater than control groups and the degrees of the activity in monocryl, silk and catgut sutures were mild, severe and moderate at the 7th day. At the 14th day there was no iNOS activity in diabetic monocryl group. Conclusion: All of the materials have the potential capacity to be well tolerated however monocryl seemed to have more benefical effects on wound healing in diabetic subjects. es
dc.source Yilmaz, Nergiz ; Inal, Samet ; Muglali, Mehtap ; Guvenc, Tolga ; Bas, Burcu. Effects of polyglecaprone 25, silk and catgut suture materials on oral mucosa wound healing in diabetic rats : an evaluation of nitric oxide dynamics. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 15 3 2010: 22- es
dc.title Effects of polyglecaprone 25, silk and catgut suture materials on oral mucosa wound healing in diabetic rats : an evaluation of nitric oxide dynamics es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.15.e526 es

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