Tuberous sclerosis complex with oral manifestations : a case report and literature review
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Tuberous sclerosis complex with oral manifestations : a case report and literature review

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Tuberous sclerosis complex with oral manifestations : a case report and literature review

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dc.contributor.author Harutunian, Karmen es
dc.contributor.author Figueiredo, Rui es
dc.contributor.author Gay Escoda, Cosme es
dc.date.accessioned 2017-07-26T11:20:33Z
dc.date.available 2017-07-26T11:20:33Z
dc.date.issued 2011 es
dc.identifier.uri http://hdl.handle.net/10550/60141
dc.description.abstract Introduction: Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome produced by a number of genetic mutations. The disease is characterized by the development of benign tumors affecting different body systems. The most common oral manifestations of TSC are fibromas, gingival hyperplasia and enamel hypoplasia. Clinical Case: A 35-year-old woman diagnosed with TSC presented with a reactive fibroma of considerable size and rapid growth in the region of the right lower third molar. Discussion: In the present case the association of TSC with dental malpositioning gave rise to a rapidly evolving reactive fibroma of considerable diameter. Few similar cases can be found in the literature. Patients with TSC present mutations of the TSC1 and TSC2 genes, which intervene in cell cycle regulation and are important for avoiding neoplastic processes. No studies have been found associating TSC with an increased risk of oral cancer, though it has been shown that the over-expression of TSC2 could exert an antitumor effect. Careful oral and dental hygiene, together with regular visits to the dentist, are needed for the prevention and early detection of any type of oral lesion. The renal, pulmonary and cardiac alterations often seen in TSC must be taken into account for the correct management of these patients. © Medicina Oral S. L. es
dc.source Harutunian, Karmen ; Figueiredo, Rui ; Gay Escoda, Cosme. Tuberous sclerosis complex with oral manifestations : a case report and literature review. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 16 4 2011: 3- es
dc.title Tuberous sclerosis complex with oral manifestations : a case report and literature review es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.16.e478 es

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