P53 and bcl-2 immunoexpression in patients with oral lichen planus a nd oral squamous cell carcinoma
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P53 and bcl-2 immunoexpression in patients with oral lichen planus a nd oral squamous cell carcinoma

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P53 and bcl-2 immunoexpression in patients with oral lichen planus a nd oral squamous cell carcinoma

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dc.contributor.author Leyva Huerta, Elba Rosa es
dc.contributor.author Ledesma Montes, Constantino es
dc.contributor.author Rojo Botello, Rebeca Estela es
dc.contributor.author Vega Memije, María Elisa es
dc.date.accessioned 2017-07-24T11:03:28Z
dc.date.available 2017-07-24T11:03:28Z
dc.date.issued 2012 es
dc.identifier.uri http://hdl.handle.net/10550/59881
dc.description.abstract Objective : The aim of this study was to determine by immunohistochemistry the presence and significance of p53 and bcl-2 proteins in oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC). Study D esign : We used 21 cases diagnosed as OLP 16 diagnosed as OSCC and four normal gingival biopsies taken from healthy patients were used as controls. Slides were processed for immunohistochemistry using anti-p53 and anti-bcl-2 monoclonal antibodies. Results : We found p53 immunoexpression in 71.4 % OLP cases and 68.7 % OSCC cases, with no immunoexpression in control cases. Bcl-2 was negative for all OLP and OSCC cases, and mild positivity was observed in normal tissue. We found significant correlation among p53 expression and OSCC malignancy. Conclusions : Our results suggest that TP53 system mainly promotes a hyperproliferative state by cell cycle arrest of the OLP epithelial cells for repairing damaged DNA nor apoptosis and that anti-apoptotic action of bcl-2 is not important in this disease. es
dc.source Leyva Huerta, Elba Rosa ; Ledesma Montes, Constantino ; Rojo Botello, Rebeca Estela ; Vega Memije, María Elisa. P53 and bcl-2 immunoexpression in patients with oral lichen planus a nd oral squamous cell carcinoma. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 17 5 2012: 18- es
dc.title P53 and bcl-2 immunoexpression in patients with oral lichen planus a nd oral squamous cell carcinoma es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.18013 es

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