?Reliability of new poly (lactic-co-glycolic acid) membranes treated with oxygen plasma plus silicon dioxide layers for pre-prosthetic guided bone regeneration processes?
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?Reliability of new poly (lactic-co-glycolic acid) membranes treated with oxygen plasma plus silicon dioxide layers for pre-prosthetic guided bone regeneration processes?

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?Reliability of new poly (lactic-co-glycolic acid) membranes treated with oxygen plasma plus silicon dioxide layers for pre-prosthetic guided bone regeneration processes?

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dc.contributor.author Castillo Dalí, Gabriel es
dc.contributor.author Castillo de Oyagüe, Raquel es
dc.contributor.author Batista Cruzado, Antonio es
dc.contributor.author López Santos, Carmen es
dc.contributor.author Rodríguez González Elipe, Agustín es
dc.contributor.author Saffar, Jean Louis es
dc.contributor.author Lynch, Christopher D. es
dc.contributor.author Gutiérrez Pérez, José Luis es
dc.contributor.author Torres-Lagares, Daniel es
dc.date.accessioned 2017-07-24T07:14:30Z
dc.date.available 2017-07-24T07:14:30Z
dc.date.issued 2017 es
dc.identifier.uri http://hdl.handle.net/10550/59827
dc.description.abstract The use of cold plasmas may improve the surface roughness of poly(lactic-co-glycolic) acid (PLGA) membranes, which may stimulate the adhesion of osteogenic mediators and cells, thus accelerating the biodegradation of the barriers. Moreover, the incorporation of metallic-oxide particles to the surface of these membranes may enhance their osteoinductive capacity. Therefore, the aim of this paper was to evaluate the reliability of a new PLGA membrane after being treated with oxygen plasma (PO2) plus silicon dioxide (SiO2) layers for guided bone regeneration (GBR) processes. Circumferential bone defects (diameter: 11 mm; depth: 3 mm) were created on the top of eight experimentation rabbits? skulls and were randomly covered with: (1) PLGA membranes (control), or (2) PLGA/PO2/SiO2 barriers. The animals were euthanized two months afterwards. A micromorphologic study was then performed using ROI (region of interest) colour analysis. Percentage of new bone formation, length of mineralised bone, concentration of osteoclasts, and intensity of ostheosynthetic activity were assessed and compared with those of the original bone tissue. The Kruskal-Wallis test was applied for between-group com Asignificance level of a=0.05 was considered. The PLGA/PO2/SiO2 membranes achieved the significantly highest new bone formation, length of mineralised bone, concentration of osteoclasts, and ostheosynthetic activity. The percentage of regenerated bone supplied by the new membranes was similar to that of the original bone tissue. Unlike what happened in the control group, PLGA/PO2/SiO2 membranes predominantly showed bone layers in advanced stages of formation. The addition of SiO2 layers to PLGA membranes pre-treated with PO2 improves their bone-regeneration potential. Although further research is necessary to corroborate these conclusions in humans, this could be a promising strategy to rebuild the bone architecture prior to rehabilitate edentulous areas. es
dc.source Castillo Dalí, Gabriel ; Castillo de Oyagüe, Raquel ; Batista Cruzado, Antonio ; López Santos, Carmen ; Rodríguez González Elipe, Agustín ; Saffar, Jean Louis ; Lynch, Christopher D. ; Gutiérrez Pérez, José Luis ; Torres-Lagares, Daniel. ?Reliability of new poly (lactic-co-glycolic acid) membranes treated with oxygen plasma plus silicon dioxide layers for pre-prosthetic guided bone regeneration processes?. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 22 2 2017: 15- es
dc.title ?Reliability of new poly (lactic-co-glycolic acid) membranes treated with oxygen plasma plus silicon dioxide layers for pre-prosthetic guided bone regeneration processes? es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.21512 es

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