Sjogren?s syndrome : review of the aetiology, Pathophysiology and Potential therapeutic interventions
NAGIOS: RODERIC FUNCIONANDO

Sjogren?s syndrome : review of the aetiology, Pathophysiology and Potential therapeutic interventions

DSpace Repository

Sjogren?s syndrome : review of the aetiology, Pathophysiology and Potential therapeutic interventions

Show simple item record

dc.contributor.author Nair, Jisha J. es
dc.contributor.author Singh, Tejas P. es
dc.date.accessioned 2017-07-19T06:50:11Z
dc.date.available 2017-07-19T06:50:11Z
dc.date.issued 2017 es
dc.identifier.uri http://hdl.handle.net/10550/59658
dc.description.abstract Sjogren?s syndrome (SS) is an autoimmune disorder characterised by lymphocytic infiltration of exocrine glands, resulting in glandular dysfunction. Objectives: This study aims to review the aetiology of Sjogren?s syndrome, highlight aspects that contribute to the pathophysiology of the disease and explore treatment options that target different mediators of pathogenesis. The MEDLINE/PubMed and Google Scholar databases were searched systematically with the terms ?Sjogren?s syndrome?; ?clinical?; ?treatment?; ?management?. Eligible studies had to meet a predefined inclusion criteria. 912 identified studies were evaluated against the inclusion criteria. 25 eligible studies were included for review. Sjogren?s syndrome is a multifactorial condition with genetic, environmental and hormonal factors playing a role in establishing the condition. B-cell activating factor (BAFF) is an important mediator in the induction and perpetuation of this condition. Elevated BAFF levels, found in patients with SS, promote growth of B-cells and subsequent production of autoantibody; anti-SSA/Ro. BAFF inhibitors are important potential therapeutic drugs that may be effective in patients with Sjogren?s syndrome. Other potential targets include CD20 and CD22 that cause B-cell depletion. The pathophysiology of this exocrinopathy has not fully been elucidated. Potential therapeutic interventions include BAFF inhibitors and anti-CD20 and anti-CD22 therapy. However, no clinical trials have been conducted on subjects with Sjogren?s syndrome to support existing research. es
dc.source Nair, Jisha J. ; Singh, Tejas P.. Sjogren?s syndrome : review of the aetiology, Pathophysiology and Potential therapeutic interventions. En: Journal of Clinical and Experimental Dentistry, 9 4 2017: 584-589 es
dc.title Sjogren?s syndrome : review of the aetiology, Pathophysiology and Potential therapeutic interventions es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/jced.53605 es

View       (456.0Kb)

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search

Browse

Statistics