Prophylaxis and antibiotic therapy in management protocols of patients treated with oral and intravenous bisphosphonates
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Prophylaxis and antibiotic therapy in management protocols of patients treated with oral and intravenous bisphosphonates

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Prophylaxis and antibiotic therapy in management protocols of patients treated with oral and intravenous bisphosphonates

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dc.contributor.author Bermúdez Bejarano, Elena Beatriz es
dc.contributor.author Serrera Figallo, María Angeles es
dc.contributor.author Gutiérrez Corrales, Aida es
dc.contributor.author Romero Ruiz, Manuel María es
dc.contributor.author Castillo de Oyagüe, Raquel es
dc.contributor.author Gutiérrez Pérez, José Luis es
dc.contributor.author Torres Lagares, Daniel es
dc.date.accessioned 2017-05-10T11:17:39Z
dc.date.available 2017-05-10T11:17:39Z
dc.date.issued 2017 es
dc.identifier.uri http://hdl.handle.net/10550/58455
dc.source Bermúdez Bejarano, Elena Beatriz ; Serrera Figallo, María Angeles ; Gutiérrez Corrales, Aida ; Romero Ruiz, Manuel María ; Castillo de Oyagüe, Raquel ; Gutiérrez Pérez, José Luis ; Torres-Lagares, Daniel. Prophylaxis and antibiotic therapy in management protocols of patients treated with oral and intravenous bisphosphonates. En: Journal of Clinical and Experimental Dentistry. 2017. Vol. 9, no. 1: 141 es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Prophylaxis and antibiotic therapy in management protocols of patients treated with oral and intravenous bisphosphonates es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÃ DICAS es
dc.description.abstractenglish Osteonecrosis of the jaw (MRONJ) linked to bisphosphonate treatment has specific characteristics that render its therapeutic management challenging for clinicians. Poor response to standard treatment makes it essential to take special precautions when treating this type of disease; therefore, antibiotic prophylaxis and/or antibiotic therapy have been proposed as effective and helpful tools in these situations. This article seeks to assess published evidence in order to evaluate the different protocols used for antibiotic prophylaxis and/or antibiotic therapy in the general context of patients treated with bisphosphonates. A literature review of the last 10 years was carried out in PubMed using the following keywords: “antibiotic prophylaxis and osteonecrosis,” “bisphosphonates AND osteonecrosis AND dental management,” “bisphosphonate AND osteonecrosis AND antibiotic prophylaxis AND oral surgery.” A total of 188 articles were obtained, of which 18 were ultimately selected. In patients treated with oral and intravenous bisphosphonates without chemotherapy-associated osteonecrosis of the jaw, antibiotic prophylaxis prior to oral surgery is an important tool to avoid osteonecrosis and promote healing of the affected area. If the patient previously exhibited chemotherapy-associated osteonecrosis after tooth extraction, antibiotic prophylaxis is indicated to prevent recurrent osteonecrosis and promote healing of the extraction site. If chemotherapy-associated osteonecrosis is already present, antibiotic therapy is a vital part of conservative management to reduce the symptomatology of MRONJ and keep it from worsening. Finally, a lack of clinical data and randomized controlled trials makes it difficult to choose the most appropriate protocol for the various clinical situations studied. es

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