Membrane protein integration into the Endoplasmic Reticulum
NAGIOS: RODERIC FUNCIONANDO

Membrane protein integration into the Endoplasmic Reticulum

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Membrane protein integration into the Endoplasmic Reticulum

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Martínez Gil, Luis; Saurí Peris, Ana; Martí Renom, Marc A.; Mingarro Muñoz, Ismael Perfil
This document is a artículoDate2011

Este documento está disponible también en : http://hdl.handle.net/10550/56204
Most integral membrane proteins are targeted, inserted and assembled in the endoplasmic reticulum (ER) membrane. The sequential and potentially overlapping events necessary for membrane protein integration take place at sites termed translocons, which comprise a specific set of membrane proteins acting in concert with ribosomes and, probably, molecular chaperones to ensure the success of the whole process. In this minireview, we summarize our current understanding of helical membrane protein integration at the endoplasmic reticulum, and highlight specific characteristics that affect the biogenesis of multispanning membrane proteins.

    Martínez Gil, Luis Saurí Peris, Ana Martí Renom, Marc A. Mingarro Muñoz, Ismael 2011 Membrane protein integration into the Endoplasmic Reticulum Febs Journal 278 20 3846 3858
http://dx.doi.org/10.1111/j.1742-4658.2011.08185.x

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