Plant virus cell-to-cell movement is not dependent on the transmembrane disposition of its movement protein
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Plant virus cell-to-cell movement is not dependent on the transmembrane disposition of its movement protein

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Plant virus cell-to-cell movement is not dependent on the transmembrane disposition of its movement protein

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Martínez Gil, Luis; Sánchez Navarro, Jesús A.; Cruz, Antonio; Pallás Benet, Vicente; Pérez Gil, Jesús; Mingarro Muñoz, Ismael Perfil
Aquest document és un/a article, creat/da en: 2009
The cell-to-cell transport of plant viruses depends on one or more virus-encoded movement proteins (MPs). Some MPs are integral membrane proteins that interact with the membrane of the endoplasmic reticulum, but a detailed understanding of the interaction between MPs and biological membranes has been lacking. The cell-to-cell movement of the Prunus necrotic ringspot virus (PNRSV) is facilitated by a single MP of the 30K superfamily. Here, using a myriad of biochemical and biophysical approaches, we show that the PNRSV MP contains only one hydrophobic region (HR) that interacts with the membrane interface, as opposed to being a transmembrane protein. We also show that a proline residue located in the middle of the HR constrains the structural conformation of this region at the membrane interface, and its replacement precludes virus movement.

    Martínez Gil, Luis Sánchez Navarro, Jesús A. Cruz, Antonio Pallás Benet, Vicente Pérez Gil, Jesús Mingarro Muñoz, Ismael 2009 Plant virus cell-to-cell movement is not dependent on the transmembrane disposition of its movement protein Journal of Virology 83 11 5535 5543
http://dx.doi.org/10.1128/JVI.00393-09
distribuït sota llicència Creative Commons de Reconeixement-NoComercial 3.0 No adaptada

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