Prevention of medication-related osteonecrosis of the jaws secondary to tooth extractions: a systematic review
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Prevention of medication-related osteonecrosis of the jaws secondary to tooth extractions: a systematic review

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Prevention of medication-related osteonecrosis of the jaws secondary to tooth extractions: a systematic review

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dc.contributor.author Diniz Freitas, Márcio es
dc.contributor.author Limeres Posse, Jacobo es
dc.date.accessioned 2016-07-26T11:55:29Z
dc.date.available 2016-07-26T11:55:29Z
dc.date.issued 2016 es
dc.identifier.uri http://hdl.handle.net/10550/54749
dc.relation es
dc.source Diniz Freitas, Márcio ; Limeres Posse, Jacobo. Prevention of medication-related osteonecrosis of the jaws secondary to tooth extractions: a systematic review. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2016, : 250- es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Prevention of medication-related osteonecrosis of the jaws secondary to tooth extractions: a systematic review es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Background: A study was made to identify the most effective protocol for reducing the risk of osteonecrosis of the jaws (ONJ) following tooth extraction in patients subjected to treatment with antiresorptive or antiangiogenic drugs. Material and Methods: A MEDLINE and SCOPUS search (January 2003 - March 2015) was made with the purpose of conducting a systematic literature review based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. All articles contributing information on tooth extractions in patients treated with oral or intravenous antiresorptive or antiangiogenic drugs were included. Results: Only 13 of the 380 selected articles were finally included in the review: 11 and 5 of them offered data on patients treated with intravenous and oral bisphosphonates, respectively. No randomized controlled trials were found – all publications corresponding to case series or cohort studies. The prevalence of ONJ in the patients treated with intravenous and oral bisphosphonates was 6,9% (range 0-34.7%) and 0.47% (range 0-2.5%), respectively. The main preventive measures comprised local and systemic infection control. Conclusions: No conclusive scientific evidence is available to date on the efficacy of ONJ prevention protocols in patients treated with antiresorptive or antiangiogenic drugs subjected to tooth extraction. es

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