Immunohistochemical expression of glucose transporter 1 in keratin-producing odontogenic cysts
NAGIOS: RODERIC FUNCIONANDO

Immunohistochemical expression of glucose transporter 1 in keratin-producing odontogenic cysts

DSpace Repository

Immunohistochemical expression of glucose transporter 1 in keratin-producing odontogenic cysts

Show simple item record

dc.contributor.author Vera-Sirera, Beatriz
dc.contributor.author Forner Navarro, Leopoldo
dc.contributor.author Vera Sempere, Francisco José
dc.date.accessioned 2016-07-01T12:48:26Z
dc.date.available 2016-07-01T12:48:26Z
dc.date.issued 2016
dc.identifier.uri http://hdl.handle.net/10550/54334
dc.description.abstract Background: Keratin-producing odontogenic cysts (KPOCs) are a group of cystic lesions that are often aggressive, with high rates of recurrence and multifocality. KPOCs included orthokeratinised odontogenic cyst (OOC) and parakeratotic odontogenic cysts, which are now considered true tumours denominated keratocystic odontogenic tumours (KCOTs). GLUT1 is a protein transporter that is involved in the active uptake of glucose across cell membranes and that is overexpressed in tumours in close correlation with the proliferation rate and positron emission tomography (PET) imaging results. Methods: A series of 58 keratin-producing odontogenic cysts was evaluated histologically and immunohistochemically in terms of GLUT1 expression. Different data were correlated using the beta regression model in relation to histological type and immunohistochemical expression of GLUT1, which was quantified using two different morphological methods. Results: KPOC cases comprised 12 OOCs and 46 KCOTs, the latter corresponding to 6 syndromic and 40 sporadic KCOTs. GLUT1 expression was very low in OOC cases compared with KCOT cases, with statistical significant differences when quantification was considered. Different GLUT1 localisation patterns were revealed by immunostaining, with the parabasal cells showing higher reactivity in KCOTs. However, among KCOTs cases, GLUT1 expression was unable to establish differences between syndromic and sporadic cases. Conclusions: GLUT1 expression differentiated between OOC and KCOT cases, with significantly higher expression in KCOTs, but did not differentiate between syndromic and sporadic KCOT cases. However, given the structural characteristics of KCOTs, we hypothesised that PET imaging methodology is probably not a useful diagnostic tool for KCOTs. Further studies of GLUT1 expression and PET examination in KCOT series are needed to confirm this last hypothesis. Keywords: Glucose transporter protein, Immunohistochemistry, Keratin-producing odontogenic cyst, Keratocystic odontogenic tumour, Orthokeratinised odontogenic cyst, Positron emission tomography
dc.language.iso eng
dc.relation.ispartof Bmc Oral Health, 2016, vol. 16, num. 1, p. 32
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Vera-Sirera, Beatriz; Forner Navarro, Leopoldo; Vera-Sempere, Francisco Jose (2016) Immunohistochemical expression of glucose transporter 1 in keratin-producing odontogenic cysts Bmc Oral Health 16 1 32
dc.subject Patologia
dc.subject Càncer
dc.subject Odontologia
dc.title Immunohistochemical expression of glucose transporter 1 in keratin-producing odontogenic cysts
dc.type info:eu-repo/semantics/article
dc.date.updated 2016-07-01T12:48:26Z
dc.identifier.doi http://dx.doi.org/10.1186/s12903-016-0191-2
dc.identifier.idgrec 109978

View       (1.331Mb)

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search

Browse

Statistics