Highly enantioselective copper(I)-catalyzed conjugate addition of 1,3-diynes to α,β-unsaturated trifluoromethyl ketones
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Highly enantioselective copper(I)-catalyzed conjugate addition of 1,3-diynes to α,β-unsaturated trifluoromethyl ketones

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Highly enantioselective copper(I)-catalyzed conjugate addition of 1,3-diynes to α,β-unsaturated trifluoromethyl ketones

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Sanz Marco, Amparo; Blay Llinares, Gonzalo Perfil; Muñoz, M. Carmen; Pedro, José Ramón
This document is a artículoDate2015

Este documento está disponible también en : http://hdl.handle.net/10550/54140
The conjugate diynylation of a,b-unsaturated trifluoromethyl ketones is carried out in the presence of a low catalytic load (2.5 mol%) of a copper(I)-MeOBIPHEP complex, triethylamine and a terminal 1,3-diyne. Pre-metalation of the terminal 1,3-diyne with stoichiometric or higher amounts of dialkylzinc reagent is not required. The corresponding internal diynes bearing a propargylic stereogenic center are obtained with good yields and excellent enantioselectivities.

    Sanz Marco, Amparo Blay Llinares, Gonzalo Muñoz, M. Carmen Pedro, José Ramón 2015 Highly enantioselective copper(I)-catalyzed conjugate addition of 1,3-diynes to α,β-unsaturated trifluoromethyl ketones Chemical Communications 51 8958 8961
http://dx.doi.org/10.1039/c5cc01676b

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