Non-invasive diagnostic tools in early detection of oral epithelial dysplasia
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Non-invasive diagnostic tools in early detection of oral epithelial dysplasia

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Non-invasive diagnostic tools in early detection of oral epithelial dysplasia

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dc.contributor.author Sharma, Navneet es
dc.contributor.author Khan, Mubeen es
dc.date.accessioned 2016-06-20T07:12:22Z
dc.date.available 2016-06-20T07:12:22Z
dc.date.issued 2011 es
dc.identifier.uri http://hdl.handle.net/10550/54114
dc.source Sharma, Navneet ; Khan, Mubeen. Non-invasive diagnostic tools in early detection of oral epithelial dysplasia. En: Journal of Clinical and Experimental Dentistry, 2011, Vol. 3, No. 3: 184-188 es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Non-invasive diagnostic tools in early detection of oral epithelial dysplasia es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Objective: The incidence of oral cancer worldwide varies 2-18% and in India 0.1 to 13.5%. Early evaluation of oral precancerous lesions can have dramatic effect on oral cancer mortality rate. Among the premalignant stage, leukoplakia is the most commonly encountered clinical lesion and epithelial dysplasia is most important predictive factor. The objective of this paper is to compare the efficacy of exfoliative cytology, toluidine blue and chemiluminescent illumination (VIZILITE) to detect early dysplastic changes in leukoplakia. Study design: Study involved 50 patients of leukoplakia (homogeneous, speckled) in the age group of 20-72 years including males and females in the ratio of 7:3. All the diagnostic procedures were carried out on each patient followed by biopsy and data was subjected to statistical analysis. Results: Comparing the results of exfoliative cytology with toluidine blue in diagnosing dysplasia in leukoplakia, it showed 50% sensitivity and 83.3 % specificity. In comparison to chemiluminescent light examination, cytology showed 42.9% sensitivity and 79.3% specificity. Chemiluminescent light examination showed 60% sensitivity and 70% specificity compared to toluidine blue. Conclusions: Overall accuracy of exfoliative cytology was less than toluidine blue, whereas latter showed superior but comparable results to chemiluminescent illumination in detecting dysplasia. However role of chemiluminescent illumination should be further investigated in demarcating dysplatic lesions es

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