Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitis: a case-control study
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Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitis: a case-control study

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Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitis: a case-control study

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dc.contributor.author García Delaney, Cristina es
dc.contributor.author Sánchez Garcés, María Angeles es
dc.contributor.author Figueiredo, Rui es
dc.contributor.author Sánchez Torres, Alba es
dc.contributor.author Gay Escoda, Cosme es
dc.date.accessioned 2016-01-20T11:01:38Z
dc.date.available 2016-01-20T11:01:38Z
dc.date.issued 2015 es
dc.identifier.uri http://hdl.handle.net/10550/50140
dc.relation http://dialnet.unirioja.es/servlet/citart?info=link&codigo=5277083&orden=0 es
dc.source García Delaney, Cristina ; Sánchez Garcés, María Angeles ; Figueiredo, Rui ; Sánchez Torres, Alba ; Gay Escoda, Cosme. Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitis: a case-control study. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 6: 12- es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitis: a case-control study es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Background: Interleukin-1 (IL-1) is a proinflammatory cytokine that plays an important role in the pathogenesis of periodontitis, and so it might be useful to detect high-risk cases of peri-implantitis. It has been reported that IL-1 polymorphisms and smoking habit have a synergic effect, increasing the incidence of peri-implantitis. The aim of the present study was to evaluate the relationship between IL-1 gene polymorphisms and peri-implantitis in smoking patients. Material and Methods: A case-control study was performed in 27 patients with peri-implantitis and 27 patients with healthy implants. All patients included were smokers. IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C were identified by polymerase chain reaction (PCR) amplification in order to establish a relation between these variables and the presence of peri-implantitis. A bivariate analysis was performed and odds-ratio (OR) were calculated. Results: The incidence of peri-implantitis was significantly higher in patients with previous history of periodontitis ( p =0.024; OR=10.9). Both groups were similar regarding IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C genotypes. No increased risk in heavy smokers with IL-1 polymorphism was found. Conclusions: IL-1 genotypes do not seem to be good predictors of peri-implantitis in the great majority of smoking patients. Furthermore, no synergic effect was found between IL-1 genotypes and heavy smokers. Patients with a previous history of periodontitis were more prone to peri-implantitis. es

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