Wired for motherhood: induction of maternal care but not maternal aggression in virgin female CD1 mice
NAGIOS: RODERIC FUNCIONANDO

Wired for motherhood: induction of maternal care but not maternal aggression in virgin female CD1 mice

DSpace Repository

Wired for motherhood: induction of maternal care but not maternal aggression in virgin female CD1 mice

Show simple item record

dc.contributor.author Martín-Sánchez, A.
dc.contributor.author Valera-Marín, G.
dc.contributor.author Hernández Martínez, Adoración
dc.contributor.author Lanuza Navarro, Enrique
dc.contributor.author Martínez-García, Fernando
dc.contributor.author Agustín-Pavón, Carmen
dc.date.accessioned 2015-12-22T13:12:37Z
dc.date.available 2015-12-22T13:12:37Z
dc.date.issued 2015
dc.identifier.uri http://hdl.handle.net/10550/49733
dc.description.abstract Virgin adult female mice display nearly spontaneous maternal care towards foster pups after a short period of sensitization. This indicates that maternal care is triggered by sensory stimulation provided by the pups and that its onset is largely independent on the physiological events related to gestation, parturition and lactation. Conversely, the factors influencing maternal aggression are poorly understood. In this study, we sought to characterize two models of maternal sensitization in the outbred CD1 strain. To do so, a group of virgin females (godmothers) were exposed to continuous cohabitation with a lactating dam and their pups from the moment of parturition, whereas a second group (pup-sensitized females), were exposed 2 h daily to foster pups. Both groups were tested for maternal behavior on postnatal days 2-4. Godmothers expressed full maternal care from the first test. Also, they expressed higher levels of crouching than dams. Pup-sensitized females differed from dams in all measures of pup-directed behavior in the first test, and expressed full maternal care after two sessions of contact with pups. However, both protocols failed to induce maternal aggression toward a male intruder after full onset of pup-directed maternal behavior, even in the presence of pups. Our study confirms that adult female mice need a short sensitization period before the onset of maternal care. Further, it shows that pup-oriented and non-pup-oriented components of maternal behavior are under different physiological control. We conclude that the godmother model might be useful to study the physiological and neural bases of the maternal behavior repertoire.
dc.language.iso eng
dc.relation.ispartof Frontiers In Behavioral Neuroscience, 2015, vol. 9, num. 197, p. 1-12
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Martín-Sánchez, A.; Valera-Marín, G.; Hernández Martínez, Adoración; Lanuza Navarro, Enrique; Martínez-García, Fernando; Agustín-Pavón, Carmen (2015) Wired for motherhood: induction of maternal care but not maternal aggression in virgin female CD1 mice Frontiers In Behavioral Neuroscience 9 197 1 12
dc.subject Neurociències
dc.subject Biologia experimental
dc.title Wired for motherhood: induction of maternal care but not maternal aggression in virgin female CD1 mice
dc.type info:eu-repo/semantics/article
dc.date.updated 2015-12-22T13:12:37Z
dc.identifier.doi http://dx.doi.org/10.3389/fnbeh.2015.00197
dc.identifier.idgrec 107440

View       (1.580Mb)

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search

Browse

Statistics