A sequence motif enriched in regions bound by the Drosophila dosage compensation complex
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A sequence motif enriched in regions bound by the Drosophila dosage compensation complex

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A sequence motif enriched in regions bound by the Drosophila dosage compensation complex

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dc.contributor.author Gallach Caballero, Miguel
dc.contributor.author Arnau Llombart, Vicente
dc.contributor.author Aldecoa, Rodrigo
dc.contributor.author Marín Lozano, Ignacio
dc.date.accessioned 2015-12-16T10:14:33Z
dc.date.available 2015-12-16T10:14:33Z
dc.date.issued 2010
dc.identifier.uri http://hdl.handle.net/10550/49519
dc.description.abstract Background: In Drosophila melanogaster, dosage compensation is mediated by the action of the dosage compensation complex (DCC). How the DCC recognizes the fly X chromosome is still poorly understood. Characteristic sequence signatures at all DCC binding sites have not hitherto been found. Results: In this study, we compare the known binding sites of the DCC with oligonucleotide profiles that measure the specificity of the sequences of the D. melanogaster X chromosome. We show that the X chromosome regions bound by the DCC are enriched for a particular type of short, repetitive sequences. Their distribution suggests that these sequences contribute to chromosome recognition, the generation of DCC binding sites and/or the local spreading of the complex. Comparative data indicate that the same sequences may be involved in dosage compensation in other Drosophila species. Conclusions: These results offer an explanation for the wild-type binding of the DCC along the Drosophila X chromosome, contribute to delineate the forces leading to the establishment of dosage compensation and suggest new experimental approaches to understand the precise biochemical features of the dosage compensation system.
dc.language.iso eng
dc.relation.ispartof Bmc Genomics, 2010, vol. 11, num. 169, p. 1-14
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Gallach Caballero, Miguel Arnau Llombart, Vicente Aldecoa, Rodrigo Marín Lozano, Ignacio 2010 A sequence motif enriched in regions bound by the Drosophila dosage compensation complex Bmc Genomics 11 169 1 14
dc.subject Genètica
dc.subject Genòmica
dc.subject Expressió genètica
dc.title A sequence motif enriched in regions bound by the Drosophila dosage compensation complex
dc.type info:eu-repo/semantics/article
dc.date.updated 2015-12-16T10:14:33Z
dc.identifier.doi http://dx.doi.org/10.1186/1471-2164-11-169
dc.identifier.idgrec 064868

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