Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in Balb/C mice.
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Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in Balb/C mice.

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Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in Balb/C mice.

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dc.contributor.author Andújar Pérez, Isabel
dc.contributor.author Ríos Cañavate, José Luis
dc.contributor.author Giner Pons, Rosa María
dc.contributor.author Cerdá Nicolás, Miguel
dc.contributor.author Recio Iglesias, María del Carmen
dc.date.accessioned 2015-06-30T10:02:47Z
dc.date.available 2015-06-30T10:02:47Z
dc.date.issued 2012
dc.identifier.uri http://hdl.handle.net/10550/44863
dc.description.abstract The naphthoquinone shikonin, a major component of the root of Lithospermum erythrorhizon, now is studied as an antiinflammatory agent in the treatment of ulcerative colitis (UC). Acute UC was induced in Balb/Cmice by oral administration of 5% dextran sodium sulfate (DSS). The disease activity index was evaluated, and a histologic study was carried out. Orally administered shikonin reduces induced UC in a dose-dependent manner, preventing the shortening of the colorectum and decreasing weight loss by 5% while improving the appearance of feces and preventing bloody stools. The disease activity index score was much lower in shikonin-treated mice than in the colitic group, as well as the myeloperoxidase activity. The expression of cyclooxygenase-2 was reduced by 75%, activation of NF-κB was reduced by 44%, and that of pSTAT-3 by 47%, as well as TNF-α, IL-1β, and IL-6 production. Similar results were obtained in primary macrophages culture. This is the first report of shikonin¿s ability to attenuate acute UC induced by DSS. Shikonin acts by blocking the activation of two major targets: NF-κB and STAT-3, and thus constitutes a promising potential therapeutic agent for the management of the inflammatory bowel disease.
dc.language.iso eng
dc.relation.ispartof Evidence-based Complementary and Alternative Medicina, 2012, vol. ID 271606, p. 1 -15
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Andújar Pérez, Isabel Ríos Cañavate, José Luis Giner Pons, Rosa María Cerdá Nicolás, Miguel Recio Iglesias, María del Carmen 2012 Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in Balb/C mice. Evidence-based Complementary and Alternative Medicina ID 271606 1 15
dc.subject Farmacologia
dc.subject Antiinflamatoris
dc.title Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in Balb/C mice.
dc.type info:eu-repo/semantics/article
dc.date.updated 2015-06-30T10:02:47Z
dc.identifier.doi http://dx.doi.org/10.1155/2012/271606
dc.identifier.idgrec 102979

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