Immunohistochemical expression of MMP-2 and MMP-8 in oral squamous cell carcinoma
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Immunohistochemical expression of MMP-2 and MMP-8 in oral squamous cell carcinoma

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Immunohistochemical expression of MMP-2 and MMP-8 in oral squamous cell carcinoma

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dc.contributor.author Lawal, Ahmed O. es
dc.contributor.author Adisa, Akinyele O. es
dc.contributor.author Kolude, Bamidele es
dc.contributor.author Adeyemi, Bukola Folasade es
dc.date.accessioned 2015-06-29T11:46:23Z
dc.date.available 2015-06-29T11:46:23Z
dc.date.issued 2015 es
dc.identifier.uri http://hdl.handle.net/10550/44835
dc.source Lawal, Ahmed O. ; Adisa, Akinyele O. ; Kolude, Bamidele ; Adeyemi, Bukola Folasade. Immunohistochemical expression of MMP-2 and MMP-8 in oral squamous cell carcinoma. En: Journal of Clinical and Experimental Dentistry, 2015, Vol. 7, No. 2: 203-207 es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Immunohistochemical expression of MMP-2 and MMP-8 in oral squamous cell carcinoma es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Background: Matrix metalloproteinases (MMPs) are endopeptidases that can degrade extracellular matrix components and affect invasiveness and aggressiveness of oral squamous cell carcinoma (OSCC). The aim of this study was to examine the immunohistochemical expression of MMP-2 and MMP-8 in OSCCs in patients presenting at the Tertiary Health facility in Nigeria Materials and Methods: Formalin-fixed, paraffin-embedded (FFPE) OSCC samples diagnosed between the years 2010 and 2012 were used for his study. The FFPE were processed for MMP-2 and MMP-8 using the specifications of the manufacturer. Two investigators reviewed the slides scoring the pattern and intensity of staining as negative (0), weakly positive (+1), moderately positive (+2) and strongly positive (+3). The data were analysed using version 20 of the SPSS. The level of significance was set at P < 0.05. Results: Twenty-five OSCC consisting of 14 (56%) males and 11 females (44%) were used. The mean age was 54.6 ± 17.9 years. A higher proportion (100%) of poorly differentiated OSCC strongly expressed MMP-2 compared with the well differentiated and moderately differentiated OSSC. There was no significant difference in the expression of MMP-2 amongst the three grades of OSCC (X2 = 2.87; p = 0.17). Only 5 (20%) OSCC cases positively expressed MMP-8. Moderate expression of MMP-8 was only seen in well-differentiated OSCCs. Conclusions: This study showed that a higher proportion of poorly differentiated OSSC strongly expressed MMP-2. Eighty percent of cases that express MMP-8 were females and moderate expression of MMP-8 was seen only in well differentiated OSCC. es

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