The Rate and Molecular Spectrum of Spontaneous Mutations in Arabidopsis thaliana
NAGIOS: RODERIC FUNCIONANDO

The Rate and Molecular Spectrum of Spontaneous Mutations in Arabidopsis thaliana

Repositori DSpace/Manakin

The Rate and Molecular Spectrum of Spontaneous Mutations in Arabidopsis thaliana

Mostra el registre complet de l'element

Visualització       (1.085Mb)

Exportar a Refworks
    
Ossowski, Stephan; Schneeberger, Korbinian; Lucas Lledó, José Ignacio; Warthmann, Norman; Clark, Richard M.; Shaw, Ruth G.; Weigel, Detlef; Lynch, Michael
Aquest document és un/a article, creat/da en: 2010
To take complete advantage of information on within-species polymorphism and divergence from close relatives, one needs to know the rate and the molecular spectrum of spontaneous mutations. To this end, we have searched for de novo spontaneous mutations in the complete nuclear genomes of five Arabidopsis thaliana mutation accumulation lines that had been maintained by single-seed descent for 30 generations. We identified and validated 99 base substitutions and 17 small and large insertions and deletions. Our results imply a spontaneous mutation rate of 7 × 10−9 base substitutions per site per generation, the majority of which are G:C→A:T transitions. We explain this very biased spectrum of base substitution mutations as a result of two main processes: deamination of methylated cytosines and ultraviolet light–induced mutagenesis.

    Science (New York, N.Y.) Vol. 327 Issue 5961:
distribuït sota llicència Creative Commons de Reconeixement-NoComercial 3.0 No adaptada

Aquest element apareix en la col·lecció o col·leccions següent(s)

Mostra el registre complet de l'element

Cerca a RODERIC

Cerca avançada

Visualitza

Estadístiques