Human Endometrial Side Population Cells Exhibit Genotypic, Phenotypic and Functional Features of Somatic Stem Cells
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Human Endometrial Side Population Cells Exhibit Genotypic, Phenotypic and Functional Features of Somatic Stem Cells

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Human Endometrial Side Population Cells Exhibit Genotypic, Phenotypic and Functional Features of Somatic Stem Cells

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dc.contributor.author Cervelló Alcaraz, Irene es_ES
dc.contributor.author Gil-Sanchis, Claudia es_ES
dc.contributor.author Mas, Aymara es_ES
dc.contributor.author Delgado Rosas, Francisco Manuel es_ES
dc.contributor.author Martínez-Conejero, José Antonio es_ES
dc.contributor.author Galán, Amparo es_ES
dc.contributor.author Martínez-Romero, Alicia es_ES
dc.contributor.author Martínez, Sebastián es_ES
dc.contributor.author Navarro, Ismael es_ES
dc.contributor.author Ferro, Jaime es_ES
dc.contributor.author Horcajadas Almansa, José Antonio es_ES
dc.contributor.author Esteban, Francisco José es_ES
dc.contributor.author O'Connor Blasco, José Enrique es_ES
dc.contributor.author Pellicer Martínez, Antonio es_ES
dc.contributor.author Simón Vallés, Carlos es_ES
dc.date.accessioned 2015-06-29T10:32:27Z
dc.date.available 2015-06-29T10:32:27Z
dc.date.issued 2010 es_ES
dc.identifier.uri http://hdl.handle.net/10550/44794
dc.description.abstract During reproductive life, the human endometrium undergoes around 480 cycles of growth, breakdown and regeneration should pregnancy not be achieved. This outstanding regenerative capacity is the basis for women's cycling and its dysfunction may be involved in the etiology of pathological disorders. Therefore, the human endometrial tissue must rely on a remarkable endometrial somatic stem cells (SSC) population. Here we explore the hypothesis that human endometrial side population (SP) cells correspond to somatic stem cells. We isolated, identified and characterized the SP corresponding to the stromal and epithelial compartments using endometrial SP genes signature, immunophenotyping and characteristic telomerase pattern. We analyzed the clonogenic activity of SP cells under hypoxic conditions and the differentiation capacity in vitro to adipogenic and osteogenic lineages. Finally, we demonstrated the functional capability of endometrial SP to develop human endometrium after subcutaneous injection in NOD-SCID mice. Briefly, SP cells of human endometrium from epithelial and stromal compartments display genotypic, phenotypic and functional features of SSC. es_ES
dc.source PLoS ONE Vol. 5 Issue 6: es_ES
dc.title Human Endometrial Side Population Cells Exhibit Genotypic, Phenotypic and Functional Features of Somatic Stem Cells es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.identifier.doi 10.1371/journal.pone.0010964 es_ES
dc.identifier.idgrec 062093 es_ES

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