A Polymorphism in a Gene Encoding Perilipin 4 Is Associated with Height but not with Bone Measures in Individuals from the Framingham Osteoporosis Study
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A Polymorphism in a Gene Encoding Perilipin 4 Is Associated with Height but not with Bone Measures in Individuals from the Framingham Osteoporosis Study

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A Polymorphism in a Gene Encoding Perilipin 4 Is Associated with Height but not with Bone Measures in Individuals from the Framingham Osteoporosis Study

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dc.contributor.author Cusano, Natalie E. es_ES
dc.contributor.author Kiel, Douglas P. es_ES
dc.contributor.author Demissie, Serkalem es_ES
dc.contributor.author Karasik, David es_ES
dc.contributor.author Cupples, L. Adrienne es_ES
dc.contributor.author Corella, Dolores es_ES
dc.contributor.author Gao, Qiong es_ES
dc.contributor.author Richardson, Kris es_ES
dc.contributor.author Yiannakouris, Nikos es_ES
dc.contributor.author Ordovas, Jose M. es_ES
dc.date.accessioned 2015-06-19T10:17:58Z
dc.date.available 2015-06-19T10:17:58Z
dc.date.issued 2012 es_ES
dc.identifier.uri http://hdl.handle.net/10550/44534
dc.description.abstract There is increasing interest in identifying new pathways and candidate genes that confer susceptibility to osteoporosis. There is evidence that adipogenesis and osteogenesis may be related, including a common bone marrow progenitor cell for both adipocytes and osteoblasts. Perilipin 1 (PLIN1) and Perilipin 4 (PLIN4) are members of the PATS family of genes and are involved in lipolysis of intracellular lipid deposits. A previous study reported gender-specific associations between one polymorphism of PLIN1 and bone mineral density (BMD) in a Japanese population. We hypothesized that polymorphisms in PLIN1 and PLIN4 would be associated with bone measures in adult Caucasian participants of the Framingham Osteoporosis Study (FOS). We genotyped 1,206 male and 1,445 female participants of the FOS for four single-nucleotide polymorphism (SNPs) in PLIN1 and seven SNPs in PLIN4 and tested for associations with measures of BMD, bone ultrasound, hip geometry, and height. We found several gender-specific significant associations with the measured traits. The association of PLIN4 SNP rs8887, G>A with height in females trended toward significance after simulation testing (adjusted P = 0.07) and remained significant after simulation testing in the combined-sex model (adjusted P = 0.033). In a large study sample of men and women, we found a significant association between one SNP in PLIN4 and height but not with bone traits, suggesting that PATS family genes are not important in the regulation of bone. Identification of genes that influence human height may lead to a better understanding of the processes involved in growth and development. es_ES
dc.source Calcified tissue international Vol. 90 Issue 2: pp. 96-107 es_ES
dc.subject Perilipin 1 es_ES
dc.subject Perilipin 4 es_ES
dc.subject Bone mineral density es_ES
dc.subject Bone geometry es_ES
dc.subject Framingham Osteoporosis Study es_ES
dc.title A Polymorphism in a Gene Encoding Perilipin 4 Is Associated with Height but not with Bone Measures in Individuals from the Framingham Osteoporosis Study es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.identifier.doi 10.1007/s00223-011-9552-7 es_ES
dc.identifier.idgrec 076267 es_ES

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