Effect of the Mediterranean diet on blood pressure in the PREDIMED trial: results from a randomized controlled trial
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Effect of the Mediterranean diet on blood pressure in the PREDIMED trial: results from a randomized controlled trial

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Effect of the Mediterranean diet on blood pressure in the PREDIMED trial: results from a randomized controlled trial

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dc.contributor.author Toledo, Estefanía es_ES
dc.contributor.author Hu, Frank B. es_ES
dc.contributor.author Estruch, Ramón es_ES
dc.contributor.author Buil-Cosiales, Pilar es_ES
dc.contributor.author Corella, Dolores es_ES
dc.contributor.author Salas-Salvadó, Jordi es_ES
dc.contributor.author Covas, María-Isabel es_ES
dc.contributor.author Arós, Fernando es_ES
dc.contributor.author Gómez-Gracia, Enrique es_ES
dc.contributor.author Fiol, Miquel es_ES
dc.contributor.author Lapetra, José es_ES
dc.contributor.author Serra-Majem, Lluís es_ES
dc.contributor.author Pintó, Xavier es_ES
dc.contributor.author Lamuela-Raventós, Rosa Maria es_ES
dc.contributor.author Sáez Tormo, Guillermo es_ES
dc.contributor.author Bulló, Mònica es_ES
dc.contributor.author Ruiz-Gutiérrez, Valentina es_ES
dc.contributor.author Ros, Emilio es_ES
dc.contributor.author Sorlí Guerola, José Vicente es_ES
dc.contributor.author Martínez-González, Miguel Ángel es_ES
dc.date.accessioned 2015-06-19T07:47:44Z
dc.date.available 2015-06-19T07:47:44Z
dc.date.issued 2013 es_ES
dc.identifier.uri http://hdl.handle.net/10550/44496
dc.description.abstract BackgroundHypertension can be prevented by adopting healthy dietary patterns. Our aim was to assess the 4-year effect on blood pressure (BP) control of a randomized feeding trial promoting the traditional Mediterranean dietary pattern.MethodsThe PREDIMED primary prevention trial is a randomized, single-blinded, controlled trial conducted in Spanish primary healthcare centers. We recruited 7,447 men (aged 55 to 80 years) and women (aged 60 to 80 years) who had high risk for cardiovascular disease. Participants were assigned to a control group or to one of two Mediterranean diets. The control group received education on following a low-fat diet, while the groups on Mediterranean diets received nutritional education and also free foods; either extra virgin olive oil, or nuts. Trained personnel measured participants’ BP at baseline and once yearly during a 4-year follow-up. We used generalized estimating equations to assess the differences between groups during the follow-up.ResultsThe percentage of participants with controlled BP increased in all three intervention groups (P-value for within-group changes: P<0.001). Participants allocated to either of the two Mediterranean diet groups had significantly lower diastolic BP than the participants in the control group (−1.53 mmHg (95% confidence interval (CI) −2.01 to −1.04) for the Mediterranean diet supplemented with extra virgin olive oil, and −0.65 mmHg (95% CI -1.15 to −0.15) mmHg for the Mediterranean diet supplemented with nuts). No between-group differences in changes of systolic BP were seen.ConclusionsBoth the traditional Mediterranean diet and a low-fat diet exerted beneficial effects on BP and could be part of advice to patients for controlling BP. However, we found lower values of diastolic BP in the two groups promoting the Mediterranean diet with extra virgin olive oil or with nuts than in the control group.Trial registrationCurrent Controlled Trials ISRCTN35739639 es_ES
dc.source BMC Medicine Vol. 11 pp. 207-207 es_ES
dc.subject Mediterranean diet es_ES
dc.subject Low-fat diet es_ES
dc.subject Systolic blood pressure es_ES
dc.subject Diastolic blood pressure es_ES
dc.subject Controlled trial es_ES
dc.subject PREDIMED trial es_ES
dc.subject Monounsaturated fat es_ES
dc.subject Dietary patterns es_ES
dc.subject Olive oil es_ES
dc.subject Nuts es_ES
dc.title Effect of the Mediterranean diet on blood pressure in the PREDIMED trial: results from a randomized controlled trial es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.identifier.doi 10.1186/1741-7015-11-207 es_ES
dc.identifier.idgrec 094230 es_ES

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