Is Myeloperoxidase a Key Component in the ROS-Induced Vascular Damage Related to Nephropathy in Type 2 Diabetes?
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Is Myeloperoxidase a Key Component in the ROS-Induced Vascular Damage Related to Nephropathy in Type 2 Diabetes?

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Is Myeloperoxidase a Key Component in the ROS-Induced Vascular Damage Related to Nephropathy in Type 2 Diabetes?

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dc.contributor.author Rovira Llopis, Susana es_ES
dc.contributor.author Rocha Barajas, Milagros es_ES
dc.contributor.author Falcon, Rosa es_ES
dc.contributor.author Pablo, Carmen de es_ES
dc.contributor.author Álvarez, Ángeles es_ES
dc.contributor.author Jover, Ana es_ES
dc.contributor.author Hernández Mijares, Antonio es_ES
dc.contributor.author Víctor González, Víctor Manuel es_ES
dc.date.accessioned 2015-06-18T12:27:01Z
dc.date.available 2015-06-18T12:27:01Z
dc.date.issued 2013 es_ES
dc.identifier.uri http://hdl.handle.net/10550/44458
dc.description.abstract AbstractIt is still unclear whether microvascular complications of type 2 diabetes correlate with leukocyte-endothelium interactions and/or myeloperoxidase (MPO) levels. In the present study, we found that serum levels of glucose, the rate of ROS and MPO concentration were higher in type 2 diabetic patients. Patients with nephropathy (39.6%) presented higher MPO levels that correlate positively with the albumin/creatinine ratio (r=0.59, p<0.05). In addition, nephropatic patients showed increased leukocyte-endothelium interactions due to an undermining of polymorphonuclear leukocytes (PMN) rolling velocity and increased rolling flux and adhesion, which was accompanied by a rise in levels of the proinflammatory cytokine tumour necrosis factor alpha (TNFα) and the adhesion molecule E-selectin. Furthermore, MPO levels were positively correlated with PMN rolling flux (r=0.855, p<0.01) and adhesion (r=0.682, p<0.05). Our results lead to the hypothesis that type 2 diabetes induces oxidative stress and an increase in MPO levels and leukocyte-endothelium interactions, and that these effects correlate with the development of nephropathy. Antioxid. Redox Signal. 19, 1452–1458. es_ES
dc.source Antioxidants & Redox Signaling Vol. 19 Issue 13: pp. 1452-1458 es_ES
dc.title Is Myeloperoxidase a Key Component in the ROS-Induced Vascular Damage Related to Nephropathy in Type 2 Diabetes? es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.identifier.doi 10.1089/ars.2013.5307 es_ES
dc.identifier.idgrec 084186 es_ES
dc.identifier.idgrec 093545

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