Fragmented adipose tissue graft for bone healing: histological and histometric study in rabbits' calvaria
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Fragmented adipose tissue graft for bone healing: histological and histometric study in rabbits' calvaria

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Fragmented adipose tissue graft for bone healing: histological and histometric study in rabbits' calvaria

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dc.contributor.author Oliveira, Lidiane da Costa es
dc.contributor.author Giovanini, Allan Fernando es
dc.contributor.author Abuabara, Allan es
dc.contributor.author Klug, Luiz Gustavo es
dc.contributor.author Gonzaga, Carla Castiglia es
dc.contributor.author Zielak, João Cézar es
dc.contributor.author Urban, Cícero de Andrade es
dc.contributor.author Deliberador, Tatiana Miranda es
dc.date.accessioned 2014-05-29T07:05:55Z
dc.date.available 2014-05-29T07:05:55Z
dc.date.issued 2013 es
dc.identifier.uri http://hdl.handle.net/10550/35632
dc.source Oliveira, Lidiane da Costa ; Giovanini, Allan Fernando ; Abuabara, Allan ; Klug, Luiz Gustavo ; Gonzaga, Carla Castiglia ; Zielak, João Cézar ; Urban, Cícero de Andrade ; Deliberador, Tatiana Miranda. Fragmented adipose tissue graft for bone healing: histological and histometric study in rabbits' calvaria. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2013, Vol. 18, No. 3: 510-515 es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Fragmented adipose tissue graft for bone healing: histological and histometric study in rabbits' calvaria es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Objective The adipose tissue represents an important reservoir of stem cells. There are few studies in the literature with which to histologically evaluate whether or not the adipose tissue graft is really a safe option to achieve bone repair. This study histologically analyzed the effect of fragmented autogenous adipose tissue grafts on bone healing in surgically created, critical-size defects (CSD) in a rabbit's calvaria. Study design Forty-two New Zealand rabbits were used in this study. CSD that were 15 mm in diameter were created in the calvarium of each animal. The defects were randomly divided into two groups: in Group C (control), the defect was filled only by a blood clot and, in Group FAT (i.e., fragmented adipose tissue), the defect was filled with fragmented autogenous adipose tissue grafts. The groups were divided into subgroups (n = 7) for euthanasia at 7, 15, and 40 days after the procedure had been conducted. Histologic and histometric analyses were performed. Data were statistically analysed with ANOVA and Tukey's tests (p < 0.05). Results The amount of bone formation did not show statistically significant differences seven days after the operation, which indicates that the groups had similar amounts of mineral deposition in the earlier period of the repair. Conversely, a significant of amount of bone matrix deposition was identified in the FAT group at 15 and 40 days following the operation, both on the border and in the body of the defect. Such an outcome was not found in the control group. Conclusion In this study, an autologous adipose tissue graft may be considered as likely biomaterial for bone regeneration, since it positively affected the amount of bone formation in surgically created CSD in the rabbits' calvaria 40 days after the procedure had been performed. Further investigations with a longer time evaluation are warranted to determine the effectiveness of autologous adipose tissue graft in the bone healing. es

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