Short-term effect of zoledronic acid upon fracture resistance of the mandibular condyle and femoral head in an animal model
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Short-term effect of zoledronic acid upon fracture resistance of the mandibular condyle and femoral head in an animal model

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Short-term effect of zoledronic acid upon fracture resistance of the mandibular condyle and femoral head in an animal model

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dc.contributor.author Camacho Alonso, Fabio es
dc.contributor.author López Jornet, María Pía es
dc.contributor.author Vicente Hernández, Ascensión es
dc.date.accessioned 2014-05-29T07:05:46Z
dc.date.available 2014-05-29T07:05:46Z
dc.date.issued 2013 es
dc.identifier.uri http://hdl.handle.net/10550/35607
dc.source Camacho Alonso, Fabio ; López Jornet, María Pía ; Vicente Hernández, Ascensión. Short-term effect of zoledronic acid upon fracture resistance of the mandibular condyle and femoral head in an animal model. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2013, Vol. 18, No. 3: 421-426 es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Short-term effect of zoledronic acid upon fracture resistance of the mandibular condyle and femoral head in an animal model es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Objective: The aim of this study was to compare the effects in terms of resistance to fracture of the mandibular condyle and femoral head following different doses of zoledronic acid in an animal model. Study design: A total of 80 adult male Sprague-Dawley rats were included in a prospective randomized study. The animals were randomly divided into four groups of 20 rats each. Group 1 (control) received sterile saline solution, while groups 2, 3 and 4 received a accumulated dose of 0.2 mg, 0.4 mg and 0.6 mg of zoledronic acid, respectively. The animals were sacrificed 28 days after the last dose, and the right hemimandible and the right femur were removed. The fracture strength was measured (in Newtons) with a universal test machine using a 1 kN load connected to a metal rod with one end angled at 30 degrees. The cross-head speed was 1 mm/min. Later, the specimens were observed under a scanning electron microscope with backscattered electron imaging (SEM- BSE). At last, chemical analysis and elemental mapping of the mineral bone composition were generated using a microanalytical system based on energy-dispersive and X-ray spectrometry (EDX). Results: A total of 160 fracture tests were performed. The fracture resistance increased in mandible and femur with a higher accumulated dose of zoledronic acid. Statistically significant differences were recorded versus the controls with all the studies groups. The chemical analysis in mandible showed a significantly increased of calcium and phosphorous to compare the control with all of the study groups; however, in femur no statistically significant differences between the four study groups were observed. Conclusions: The administration of bisphosphonates increases the fracture resistance in mandible and femur. es

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