Prognosis factors in the treatment of bisphosphonate-related osteonecrosis of the jaw - Prognostic factors in the treatment of BRONJ -
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Prognosis factors in the treatment of bisphosphonate-related osteonecrosis of the jaw - Prognostic factors in the treatment of BRONJ -

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Prognosis factors in the treatment of bisphosphonate-related osteonecrosis of the jaw - Prognostic factors in the treatment of BRONJ -

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dc.contributor.author Yoshiga, Daigo es
dc.contributor.author Nakamichi, Ikuo es
dc.contributor.author Yamashita, Yoshihiro es
dc.contributor.author Yamamoto, Noriaki es
dc.contributor.author Yamauchi, Kensuke es
dc.contributor.author Nogami, Shinnosuke es
dc.contributor.author Kaneuji, Takeshi es
dc.contributor.author Mitsugi, Sho es
dc.contributor.author Tanaka, K. es
dc.contributor.author Kataoka, Yoshihiro es
dc.contributor.author Sakurai, Takuma es
dc.contributor.author Kiyomiya, Hiroyasu es
dc.contributor.author Miyamoto, Ikuya es
dc.contributor.author Takahashi, Tetsu es
dc.date.accessioned 2014-05-22T10:05:37Z
dc.date.available 2014-05-22T10:05:37Z
dc.date.issued 2014 es
dc.identifier.uri http://hdl.handle.net/10550/35369
dc.source Yoshiga, Daigo ; Nakamichi, Ikuo ; Yamashita, Yoshihiro ; Yamamoto, Noriaki ; Yamauchi, Kensuke ; Nogami, Shinnosuke ; Kaneuji, Takeshi ; Mitsugi, Sho ; Tanaka, K. ; Kataoka, Yoshihiro ; Sakurai, Takuma ; Kiyomiya, Hiroyasu ; Miyamoto, Ikuya ; Takahashi, Tetsu. Prognosis factors in the treatment of bisphosphonate-related osteonecrosis of the jaw - Prognostic factors in the treatment of BRONJ -. En: Journal of Clinical and Experimental Dentistry, 2014, Vol. 6, No. 1: 22-28 es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Prognosis factors in the treatment of bisphosphonate-related osteonecrosis of the jaw - Prognostic factors in the treatment of BRONJ - es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Objectives: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a relatively rare but serious side effect of bisphosphonate (BP)-based treatments. This retrospective study aimed to investigate the risk factors and predictive markers in cases where patients were refractory to a recommended conservative treatment offered in our hospital. Patients and Methods: This single-center study collated the medical records of all patients treated for BRONJ between 2004 and 2011. A complete medical history, including detailed questionnaires, was collected for all patients, focusing on identifying underlying risk factors, clinical features, location and bone marker levels of BRONJ. Results: The mean BRONJ remission rate was 57.6%, and the median duration of remission was seven months. Eighteen patients (34.6%) had persistent or progressive disease with a recommended conservative treatment for BRONJ. Notably, urinary cross-linked N-terminal telopeptide of type 1 collagen (NTX) levels in those resistant to conservative treatment tended to be lower than in patients that healed well. Conclusions: We confirm that a significant proportion of BRONJ sufferers are refractory to a recommended conservative treatment and find that anticancer drugs, periodontal disease, the level of bone exposure and the dosage of intravenous BPs (e.g. zoledronate) represent specific risk factors in BRONJ that may determine the success of a recommended conservative treatment. Additionally, the NTX levels might be able to be a prognostic factor for the conservative treatment of BRONJ; additional research is necessary. es

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