The generation of oligodendroglial cells is preserved in the rostral migratory stream during aging.
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The generation of oligodendroglial cells is preserved in the rostral migratory stream during aging.

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The generation of oligodendroglial cells is preserved in the rostral migratory stream during aging.

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dc.contributor.author Capilla González, Vivian
dc.contributor.author Cebrián Silla, Arantxa
dc.contributor.author Guerrero-Cazares, Hugo
dc.contributor.author García Verdugo, José Manuel
dc.contributor.author Quiñones-Hinojosa, Alfredo
dc.date.accessioned 2014-01-17T14:24:13Z
dc.date.available 2014-01-17T14:24:13Z
dc.date.issued 2013
dc.identifier.uri http://dx.doi.org/10.3389/fncel.2013.00147
dc.identifier.uri http://hdl.handle.net/10550/32376
dc.description.abstract The subventricular zone (SVZ) is the largest source of newly generated cells in the adult mammalian brain. SVZ-derived neuroblasts migrate via the rostral migratory stream (RMS) to the olfactory bulb (OB), where they differentiate into mature neurons. Additionally, a small proportion of SVZ-derived cells contribute to the generation of myelinating oligodendrocytes. The production of new cells in the SVZ decreases during aging, affecting the incorporation of new neurons into the OB. However, the age-related changes that occur across the RMS are not fully understood. In this study we evaluate how aging affects the cellular organization of migrating neuroblast chains, the proliferation, and the fate of the newly generated cells in the SVZ-OB system. By using electron microscopy and immunostaining, we found that the RMS path becomes discontinuous and its cytoarchitecture is disorganized in aged mice (24-month-old mice). Subsequently, OB neurogenesis was impaired in the aged brain while the production of oligodendrocytes was not compromised. These findings provide new insight into oligodendrocyte preservation throughout life. Further exploration of this matter could help the development of new strategies to prevent neurological disorders associated with senescence.
dc.relation.ispartof Frontiers In Cellular Neuroscience, 2013, vol. 7, num. 147, p. 1-9
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Capilla González, Vivian; Cebrián Silla, Arantxa; Guerrero-Cazares, H.; Garcia Verdugo, José Manuel; Quiñones-Hinojosa, A. (2013) The generation of oligodendroglial cells is preserved in the rostral migratory stream during aging. Frontiers In Cellular Neuroscience 7 147 1 9
dc.subject Neurones
dc.subject Cèl·lules
dc.subject Neurologia
dc.title The generation of oligodendroglial cells is preserved in the rostral migratory stream during aging.
dc.type info:eu-repo/semantics/article
dc.date.updated 2014-01-17T14:24:13Z
dc.identifier.doi http://dx.doi.org/10.3389/fncel.2013.00147
dc.identifier.idgrec 093144

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