Mechanisms underlying diabetes enhancement of endothelin-1-induced contraction in rabbit basilar artery
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Mechanisms underlying diabetes enhancement of endothelin-1-induced contraction in rabbit basilar artery

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Mechanisms underlying diabetes enhancement of endothelin-1-induced contraction in rabbit basilar artery

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dc.contributor.author Alabadí Ferrer, José Antonio
dc.contributor.author Miranda Alonso, Francisco Javier
dc.contributor.author Lloréns, Silvia
dc.contributor.author Centeno Guil, José M.
dc.contributor.author González Marrachelli, Vannina Elena
dc.contributor.author Alborch Domínguez, Enrique
dc.date.accessioned 2013-12-09T13:51:47Z
dc.date.available 2013-12-09T13:51:47Z
dc.date.issued 2004
dc.identifier.uri http://dx.doi.org/10.1016/j.ejphar.2004.01.005
dc.identifier.uri http://hdl.handle.net/10550/32082
dc.description.abstract The influence of alloxan-induced diabetes on the reactivity of rabbit basilar artery to endothelin-1 was examined. Endothelin-1 induced concentration-dependent contraction of basilar arteries that was higher in diabetic than in control rabbits. Endothelium removal produced a higher enhancement of the endothelin-1-induced contraction in control than in diabetic rabbits. NG-nitro-L-arginine (L-NOArg) enhanced the maximal contraction induced by endothelin-1 in control rabbits and potentiated this response in diabetic rabbits. Endothelin ETA receptor antagonist, cyclo(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123), inhibited endothelin-1-induced contraction in both rabbit groups. Endothelin ETB receptor antagonist, 2,6-Dimethylpiperidinecarbonyl-g-Methyl Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle (BQ-788), enhanced endothelin-1-induced contraction in control rabbits and decreased the potency of endothelin-1 in diabetic rabbits. Sodium nitroprusside-induced relaxation of basilar arteries was lower in diabetic than in control rabbits. These results suggest that mechanisms underlying rabbit basilar artery hyperreactivity to endothelin-1 include decreased endothelial modulation of endothelin-1-induced contraction, with impaired endothelial endothelin ETB receptor activity; decreased sensitivity to nitric oxide (NO) in vascular smooth muscle; and enhanced participation of muscular endothelin ETA and ETB receptors.
dc.relation.ispartof European Journal of Pharmacology, 2004, vol. 486, p. 289-296
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Alabadí Ferrer, José Antonio Miranda Alonso, Francisco Javier Lloréns, Silvia Centeno Guil, José M González Marrachelli, Vannina Elena Alborch Dominguez, Enrique 2004 Mechanisms underlying diabetes enhancement of endothelin-1-induced contraction in rabbit basilar artery. European Journal of Pharmacology 486 289 296
dc.subject Endoteli vascular
dc.subject Òxid nítric
dc.subject Diabetis
dc.subject Artèries
dc.title Mechanisms underlying diabetes enhancement of endothelin-1-induced contraction in rabbit basilar artery
dc.type info:eu-repo/semantics/article
dc.date.updated 2013-12-09T13:51:47Z
dc.identifier.doi http://dx.doi.org/10.1016/j.ejphar.2004.01.005
dc.identifier.idgrec 014187

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