A genomic study of the Inter-ORF distances in Saccharomyces cerevisiae
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A genomic study of the Inter-ORF distances in Saccharomyces cerevisiae

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A genomic study of the Inter-ORF distances in Saccharomyces cerevisiae

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dc.contributor.author Pelechano García, Vicente José
dc.contributor.author García Martínez, José
dc.contributor.author Pérez Ortín, José Enrique
dc.date.accessioned 2013-12-09T11:14:15Z
dc.date.available 2013-12-09T11:14:15Z
dc.date.issued 2006
dc.identifier.uri http://dx.doi.org/10.1002/yea.1390
dc.identifier.uri http://hdl.handle.net/10550/32076
dc.description.abstract The genome of eukaryotic microbes is usually quite compacted. The yeast Saccharomyces cerevisiae is one of the best-known examples. Open reading frames (ORFs) occupy about 75% of the total DNA sequence. The existence of other, non-protein coding genes and other genetic elements leaves very little space for gene promoters and terminators. We have performed an in silico study of inter-ORF distances that shows that there is a minimum distance between two adjacent ORFs that depends on the relative orientation between them. Our analyses suggest that different kinds of promoters and terminators exist with regard to their length and ability to overlap each other. The experimental testing of some putative exceptions to the minimum length model in tandemly orientated ORF pairs suggests that, in those cases, defects in promoter or terminator functionality exist that provoke transcription of polycistronic mRNAs.
dc.relation.ispartof Yeast, 2006, vol. 23, p. 689-699
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Pelechano García, Vicente José García Martínez, José Pérez Ortín, José Enrique 2006 A genomic study of the Inter-ORF distances in Saccharomyces cerevisiae Yeast 23 689 699
dc.subject Saccharomyces cerevisiae
dc.subject Transcripció genètica
dc.title A genomic study of the Inter-ORF distances in Saccharomyces cerevisiae
dc.type info:eu-repo/semantics/article
dc.date.updated 2013-12-09T11:14:15Z
dc.identifier.doi http://dx.doi.org/10.1002/yea.1390
dc.identifier.idgrec 026725

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